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Multiple Oxygen Tension Environments Reveal Diverse Patterns of Transcriptional Regulation in Primary Astrocytes

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Multiple Oxygen Tension Environments Reveal Diverse ~ Multiple Oxygen Tension Environments Reveal Diverse Patterns of Transcriptional Regulation in Primary Astrocytes Wayne Chadwick1., John P. Boyle2., Yu Zhou1, Liyun Wang1, Sung-Soo Park1, Bronwen Martin3, Rui Wang3, Kevin G. Becker4, William H. Wood III4, Yongqing Zhang4, Chris Peers2*", Stuart Maudsley1*" 1Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health .

GEO Accession viewer ~ Multiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytes: Organism: Rattus norvegicus: Experiment type: Expression profiling by array: Summary: The central nervous system normally functions at O2 levels which would be regarded as hypoxic by most other tissues.

Multiple Oxygen Tension Environments Reveal Diverse ~ Multiple Oxygen Tension Environments Reveal Diverse Patterns of Transcriptional Regulation in Primary Astrocytes By Wayne Chadwick, John P. Boyle, Yu Zhou, Liyun Wang, Sung-Soo Park, Bronwen Martin, Rui Wang, Kevin G. Becker, William H. Wood, Yongqing Zhang, Chris Peers and Stuart Maudsley

An effective, low-cost method for achieving and ~ Multiple Oxygen Tension Environments Reveal Diverse Patterns of Transcriptional Regulation in Primary Astrocytes. PLoS ONE 6:e21638. Crossref , Medline , CAS , Google Scholar

Sex differences in the mitochondrial bioenergetics of ~ Oxygen is 160 mm Hg (21%) in the atmosphere, while the oxygen tension in the brain generally ranges from ∼5 to 45 mm Hg (∼1–6% O 2). This study tested the hypothesis that sex and/or brain physiological oxygen tension influence the mitochondrial bioenergetic properties of primary rat cortical astrocytes and microglia.

Transcriptional Regulation of Pattern-Triggered Immunity ~ Transcriptional feedback regulation often occurs at multiple levels in a signal transduction pathway to ensure the robustness and sustainability of signaling outputs. MAMP-induced transcriptional reprogramming feeds back to modulate the expression of PRR complexes, diverse PTI signaling components and outputs at different steps to launch .

Chris PEERS / BSc PhD / University of Leeds, Leeds ~ Multiple Oxygen Tension Environments Reveal Diverse Patterns of Transcriptional Regulation in Primary Astrocytes . Multiple Oxygen Tension Environments Reveal Diverse Patterns of Transcriptional .

Oxygen impairs oligodendroglial development via oxidative ~ Chadwick, W. et al. Multiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytes. PloS one 6 , e21638, doi: 10.1371/journal.pone.0021638 (2011).

Y. ZHOU / PhD ~ Significantly regulated (p<0.05) genes in rat primary astrocytes exposed to 9% ambient O2 tension compared to 20% O2 tension. Z ratios were calculated as described in Materials and Methods. (DOC)

Frontiers / Effective use of latent semantic indexing and ~ Multiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytes. PLoS ONE 6:e21638. doi: 10.1371/journal.pone.0021638 Pubmed Abstract / Pubmed Full Text / CrossRef Full Text

VennPlex–A Novel Venn Diagram Program for Comparing and ~ Chadwick W, Boyle JP, Zhou Y, Wang L, Park SS, et al. (2011) Multiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytes. PLoS One 6: e21638. View Article Google Scholar 21.

Alzheimer’s amyloid peptides mediate hypoxic up-regulation ~ Multiple Oxygen Tension Environments Reveal Diverse Patterns of Transcriptional Regulation in Primary Astrocytes 27 June 2011 / PLoS ONE, Vol. 6, No. 6 Role of KATP and L-type Ca2+ channel activities in regulation of ovine uterine vascular contractility: effect of pregnancy and chronic hypoxia

Transcriptional Regulation in Plants: The Importance of ~ tential for TFIID to serve as a major point of regulation has also been suggested by the discovery of multiple TBPs in some species, including Arabidopsis. In D. melanogaster,in addition to a ubiquitous TBP, a second tissue-specific TBP, TRF (TBP-related factor), has been identified that may be important for neural-specific patterns of gene .

Evolution of the Couple Cyto chrome c and Cyto chrome c ~ Chadwick W, Boyle JP, Zhou Y, Wang L, Park SS, Martin B, Wang R, Becker KG, Wood WH 3rd, Zhang Y, Peers C, Maudsley S (2011) Multiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytes. PLoS One 6:e21638 PubMed Google Scholar

Glial fibrillary acidic protein exhibits altered turnover ~ Laura R. Moody, Gregory A. Barrett-Wilt, Michael R. Sussman, Albee Messing

Comparative brain oxygenation and mitochondrial redox ~ Multiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytes. Chadwick W, Boyle JP, Zhou Y, Wang L, Park SS, Martin B, Wang R, Becker KG, Wood WH, Zhang Y, Peers C, Maudsley S. PLoS One, 6(6):e21638, 27 Jun 2011

Cells / Free Full-Text / Transcriptional Regulation of ~ Foxp3-expressing regulatory T (Treg) cells can suppress the activity of various types of immune cells and play key roles in the maintenance of self-tolerance and in the regulation of immune responses against pathogens and tumor cells. Treg cells consist of heterogeneous subsets that have distinct phenotypes and functions. Upon antigen stimulation, naïve-like thymus-derived Treg cells .

Inflammation, Cytokines, Immune Response, Apolipoprotein E ~ Multiple Oxygen Tension Environments Reveal Diverse Patterns of Transcriptional Regulation in Primary Astrocytes 27 June 2011 / PLoS ONE, Vol. 6, No. 6 Oxidative Stress and Inflammation in Heart Disease: Do Antioxidants Have a Role in Treatment and/or Prevention?

Hypoxic preconditioning induces elevated expression of ~ Multiple Oxygen Tension Environments Reveal Diverse Patterns of Transcriptional Regulation in Primary Astrocytes 27 June 2011 / PLoS ONE, Vol. 6, No. 6 Stanniocalcin 1 binds hemin through a partially conserved heme regulatory motif

Dr. William Wood Jr., MD – Easton, MD / Internal Medicine ~ 16 citations Multiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytes. Chadwick W, Boyle JP, Zhou Y, Wang L, Park S, Martin B, Wang R, Becker KG, Wood WH, Zhang Y, Peers C, Maudsley S> ;PLoS ONE. 2011-01-01

GIT2 Acts as a Potential Keystone Protein in Functional ~ Multiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytes. (2005). Neonatal cerebral hypoxia-ischemia: involvement of FAK-dependent pathway. (1998). Neuropil threads are collinear with MAP2 immunostaining in neuronal dendrites of Alzheimer brain. (2001). Obesity and the regulation of energy .