Free Download Identification of Chromosomal Genes in Yersinia pestis that Influence Type III Secretion and Delivery of Yops into Target Cells Ebook, PDF Epub
Identification of Chromosomal Genes in Yersinia pestis that Influence Type III Secretion and Delivery of Yops into Target Cells
Description Identification of Chromosomal Genes in Yersinia pestis that Influence Type III Secretion and Delivery of Yops into Target Cells.
Detail Book
- Identification of Chromosomal Genes in Yersinia pestis that Influence Type III Secretion and Delivery of Yops into Target Cells PDF
- Identification of Chromosomal Genes in Yersinia pestis that Influence Type III Secretion and Delivery of Yops into Target Cells EPub
- Identification of Chromosomal Genes in Yersinia pestis that Influence Type III Secretion and Delivery of Yops into Target Cells Doc
- Identification of Chromosomal Genes in Yersinia pestis that Influence Type III Secretion and Delivery of Yops into Target Cells iBooks
- Identification of Chromosomal Genes in Yersinia pestis that Influence Type III Secretion and Delivery of Yops into Target Cells rtf
- Identification of Chromosomal Genes in Yersinia pestis that Influence Type III Secretion and Delivery of Yops into Target Cells Mobipocket
- Identification of Chromosomal Genes in Yersinia pestis that Influence Type III Secretion and Delivery of Yops into Target Cells Kindle
Book Identification of Chromosomal Genes in Yersinia pestis that Influence Type III Secretion and Delivery of Yops into Target Cells PDF ePub
Identification of Chromosomal Genes in Yersinia pestis ~ Identification of Chromosomal Genes in Yersinia pestis that Influence Type III Secretion and Delivery of Yops into Target Cells Andrew S. Houppert , 1 Elizabeth Kwiatkowski , 2 Elizabeth M. Glass , 3 Kristin L. DeBord , 2 Peter M. Merritt , 1 Olaf Schneewind , 2 and Melanie M. Marketon 1, 2, *
Identification of chromosomal genes in Yersinia pestis ~ Identification of chromosomal genes in Yersinia pestis that influence type III secretion and delivery of Yops into target cells. Houppert AS(1), Kwiatkowski E, Glass EM, DeBord KL, Merritt PM, Schneewind O, Marketon MM. Author information: (1)Department of Biology, Indiana University, Bloomington, Indiana, United States of America.
Identification of Chromosomal Genes in Yersinia pestis ~ Identification of Chromosomal Genes in Yersinia pestis that Influence Type III Secretion and Delivery of Yops into Target Cells.pdf Available via license: CC BY 4.0 Content may be subject to .
Identification of Chromosomal Genes in Yersinia pestis ~ Identification of Chromosomal Genes in Yersinia pestis that Influence Type III Secretion and Delivery of Yops into Target Cells, PLOS ONE, 2012, 3, DOI: 10.1371/journal.pone.0034039 Home About
Identification of Chromosomal Genes in Yersinia pestis ~ Pathogenic Yersinia species possess a type III secretion system, which is required for the delivery of effector Yop proteins into target cells during infection. Genes encoding the type III secretion machinery, its substrates, and several regulatory proteins all reside on a 70-Kb virulence plasmid. Genes encoded in the chromosome of yersiniae .
Chromosomally-Encoded Yersinia pestis Type III Secretion ~ Yersinia pestis, the causative agent of plague, possesses a number of virulence mechanisms that allows it to survive and proliferate during its interaction with the host. To discover additional infection-specific Y. pestis factors, a transposon site hybridization (TraSH)-based genome-wide screen was employed to identify genomic regions required for its survival during cellular infection.
Kristin L DeBord's research works / University of Chicago ~ Kristin L DeBord's 15 research works with 2,381 citations and 1,464 reads, including: Identification of Chromosomal Genes in Yersinia pestis that Influence Type III Secretion and Delivery of Yops .
Andrew S Houppert's research works / Indiana University ~ Pathogenic Yersinia species possess a type III secretion system, which is required for the delivery of effector Yop proteins into target cells during infection. Genes encoding the type III .
Genome Sequence of Yersinia pestis KIM / Journal of ~ Type III secretion systems translocate effector proteins from the bacterium directly into the mammalian host target cell. Genes of a type III system are present in the KIM chromosome, but they are more closely related to the Salmonella genes located on island SPI2 than to the Yersinia enterocolitica chromosomal locus.
Kristin L DeBord's research works / University of Chicago ~ Pathogenic Yersinia species possess a type III secretion system, which is required for the delivery of effector Yop proteins into target cells during infection. Genes encoding the type III .
Yersinia pestis - Wikipedia ~ Yersinia pestis (formerly Pasteurella pestis) is a gram-negative, non-motile, rod-shaped, coccobacillus bacterium, without spores. It is a facultative anaerobic organism that can infect humans via the Oriental rat flea (Xenopsylla cheopis). It causes the disease plague, which takes three main forms: pneumonic, septicemic, and bubonic.. All three forms have been responsible for high-mortality .
Three Yersinia pestis Adhesins Facilitate Yop Delivery to ~ To establish a successful infection, Yersinia pestis requires the delivery of cytotoxic Yops to host cells. Yops inhibit phagocytosis, block cytokine responses, and induce apoptosis of macrophages. The Y. pestis adhesin Ail facilitates Yop translocation and is required for full virulence in mice. To determine the contributions of other adhesins to Yop delivery, we deleted five known adhesins .
Illuminating Targets of Bacterial Secretion ~ Houppert AS, Kwiatkowski E, Glass EM, DeBord KL, Merritt PM, Schneewind O, et al. Identification of chromosomal genes in Yersinia pestis that influence type III secretion and delivery of Yops into target cells. PLoS ONE. 2012;7(3):e34039. pmid:22479512 . View Article PubMed/NCBI
Usurping bacterial virulence factors as self-delivery ~ Identification of chromosomal genes in Yersinia pestis that influence type III secretion and delivery of Yops into target cells. Houppert AS, Kwiatkowski E, Glass EM, DeBord KL, Merritt PM, Schneewind O, Marketon MM. PLoS One, 7(3):e34039, 30 Mar 2012
Early sensing of Yersinia pestis airway infection by bone ~ Y. pestis strains and culture conditions. The fully virulent Y. pestis Kimberley53 (Kim53) strain was grown on Brain Heart Infusion agar (BHIA, Difco) for 48 hours (h) at 28°C. For intranasal (i.n.) infection, bacterial colonies were harvested and diluted in Heart Infusion Broth (HIB, Difco) supplemented with 0.2% (+) Xylose and 2.5 mM CaCl 2 (Sigma-Aldrich) to an OD 660 of 0.01 and grown for .
Global Gene Expression Profiling of Yersinia pestis ~ Yersinia pestis is a Gram-negative bacterium and the causative agent of plague. In humans, bubonic plague can occur following the bite of an infected flea, while pneumonic plague can be spread through the inhalation of infectious droplets and is highly fatal ().Although natural outbreaks of plague have declined in recent years, plague is still endemic in regions of North and South America .
Evidence for Targeting of Yop Effectors by the ~ Yersinia enterocolitica O:8 has two contact-dependent type III secretion systems (TTSSs). The Ysa TTSS is encoded by a set of genes located on the chromosome and exports Ysp proteins. The Ysc TTSS and the Yop effector proteins it exports are encoded by genes located on plasmid pYVe8081. In this study, secretion of YspG, YspH, and YspJ by the Ysa TTSS was shown to require pYVe8081.
The NlpD Lipoprotein Is a Novel Yersinia pestis Virulence ~ Yersinia pestis is the causative agent of plague. Previously we have isolated an attenuated Y. pestis transposon insertion mutant in which the pcm gene was disrupted. In the present study, we investigated the expression and the role of pcm locus genes in Y. pestis pathogenesis using a set of isogenic surE, pcm, nlpD and rpoS mutants of the fully virulent Kimberley53 strain.
Interaction between Yersinia pestis and the Host Immune ~ It activates the secretion and translocation of effectors by binding to the negative regulator LcrG and works together with Yops B and D for delivering Yops into eukaryotic cells . It is also exposed on the bacterial cell surface prior to contact with mammalian cells and may play a role in cell-cell adhesion ( 67 ).
Yersinia pestis - ScienceDirect ~ Yersinia pestis, the causative agent of bubonic plague, has three remarkable attributes.First, it causes the most severe of all human bacterial infections as judged by historical records. Second, the emergence of Y. pestis occurred no later than 10 000 years ago and its dramatic evolution from an enteropathogen to agent of acute disease may still be in progress.
Genes / Free Full-Text / The Most Important Virulence ~ The plasmid of Yersinia virulence (pYV) with a size of 64–75 kb is the most known and important virulence marker of Y. enterocolitica [1,6].All biotypes are capable of invading intestinal mucosa, but only strains with a plasmid can migrate from Peyer’s patches to mesenteric lymph nodes and internal organs, where they multiply and lead to the necrotic abscesses formation [].
Virulence Plasmid - an overview / ScienceDirect Topics ~ Other enteric bacteria, such as Salmonella typhi (typhoid) and Y. pestis (bubonic plague), cause severe infections. They also carry virulence plasmids. In Salmonella, the majority of the virulence genes are on the chromosome, but there are also some that are plasmid-borne.In contrast, in Yersinia several plasmids carry the bulk of the virulence genes. . In addition to toxins and adhesins .
RfaL Is Required for Yersinia pestis Type III Secretion ~ Yersinia pestis, the causative agent of plague, uses a type III secretion system (T3SS) to inject cytotoxic Yop proteins directly into the cytosol of mammalian host cells. The T3SS can also be activated in vitro at 37°C in the absence of calcium. The chromosomal gene rfaL ( waaL ) was recently identified as a virulence factor required for proper function of the T3SS.
Role of Yops and Adhesins in Resistance of Yersinia ~ Yersinia enterocolitica is a pathogen endowed with two adhesins, Inv and YadA, and with the Ysc type III secretion system, which allows extracellular adherent bacteria to inject Yop effectors into the cytosol of animal target cells. We tested the influence of all of these virulence determinants on opsonic and nonopsonic phagocytosis by PU5-1.8 and J774 mouse macrophages, as well as by human .