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Impact of Hydroxychloroquine on Atherosclerosis and ~ Cardiovascular disease is the largest cause of morbidity and mortality among patients with chronic kidney disease (CKD) and end-stage kidney disease, with nearly half of all deaths attributed to cardiovascular disease. Hydroxychloroquine (HCQ), an anti-inflammatory drug, has been shown to have multiple pleiotropic actions relevant to atherosclerosis.
Effects of low-dose hydroxychloroquine on expression of ~ However, low-dose chloroquine and hydroxychloroquine (HCQ) were reported to relieve the metabolic syndrome and the extent of atherosclerosis by activating ATM (4,8,9), implying protective roles for low-dose chloroquine and HCQ, most likely in patients with coronary artery disease with ischemic cardiomyopathy. To address this issue, we performed .
Comparison of the effects of hydroxychloroquine and ~ Hydroxychloroquine (HCQ), a well-known immunomodulator, has recently been found to be a promising and safe anti-proteinuric agent for treating IgA nephropathy (IgAN). We aimed to compare the efficacy and safety of HCQ and corticosteroid treatment in patients with IgAN. This is a case-control study. Ninety-two patients with IgAN who received HCQ in addition to routine renin-angiotensin .
Hydroxychloroquine for the prevention of recurrent ~ Introduction. Studies have demonstrated that chronic inflammation is a major driving force in the pathogenesis of atherosclerosis and myocardial infarction (MI). 1 Atherosclerotic lesions in the arterial wall are characterized by the accumulation of cholesterol, and infiltration of peripheral blood monocytes-derived macrophages, T lymphocytes, and mast cells. 2–4 These immune system cells .
Hydroxychloroquine in Cardiovascular Disease in Patients ~ Hydroxychloroquine (HCQ) used as anti-inflammatory in rheumatological disorders, has multiple beneficial properties relevant to the process of vascular disease. The effects of HCQ on atherosclerosis (AS) and vascular disease in CKD is not known yet.
Hydroxychloroquine, a promising choice for coronary artery ~ Introduction to coronary artery disease and its current treatment. Coronary artery disease (CAD) is the most common cause of death (and premature death) in the China, 1 in 5 men and 1 in 7 women die from CAD .CAD is characterized as a chronic inflammatory disease, and our previous research suggested that Th17/Th1 cell and its cytokines may be key factors in CAD development .
Hydroxychloroquine Disease Interactions - Drugs ~ Hydroxychloroquine is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. A dosage adjustment is not required for patients with renal impairment.
Hydroxychloroquine: Indications, Side Effects, Warnings ~ Tell all of your health care providers that you take hydroxychloroquine. This includes your doctors, nurses, pharmacists, and dentists. A severe eye problem has happened with hydroxychloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems.
Atherosclerosis / NHLBI, NIH ~ Atherosclerosis is a disease in which plaque builds up inside your arteries. Over time, plaque hardens and narrows your arteries. Learn more about causes, risk factors, screening and prevention, signs and symptoms, diagnoses, and treatments for atherosclerosis, and how to participate in clinical trials.
Protective Effects of Hydroxychloroquine against ~ Cardiovascular (CV) morbidity and mortality are a challenge in management of patients with systemic lupus erythematosus (SLE). Higher risk of CV disease in SLE patients is mostly related to accelerated atherosclerosis. Nevertheless, high prevalence of traditional cardiovascular risk factors in SLE patients does not fully explain the increased CV risk.
The Outcome of Patients with Nephrogenic Systemic Fibrosis ~ Impact of Hydroxychloroquine on Atherosclerosis and Vascular Stiffness in the Presence of Chronic Kidney Disease. . disease. Hydroxychloroquine (HCQ), an anti-inflammatory drug, has been shown .
Chronic Hydroxychloroquine Improves Endothelial ~ Chronic hydroxychloroquine treatment reduced hypertension, endothelial dysfunction, and organ damage in severe lupus mice, despite the persistent elevation of anti–double-stranded DNA, suggesting the involvement of new additional mechanisms to improve cardiovascular complications.
Chronic Hydroxychloroquine Improves Endothelial ~ Vascular reactive oxygen species content and mRNA levels of nicotinamide adenine dinucleotide phosphate oxidase subunits NOX-1 and p47 phox were increased in lupus mice and reduced by hydroxychloroquine or antioxidants. Chronic hydroxychloroquine treatment reduced hypertension, endothelial dysfunction, and organ damage in severe lupus mice .
Cardiovascular Disease in Systemic Lupus Erythematosus ~ Hydroxychloroquine reduces low-density lipoprotein cholesterol levels in systemic lupus erythematosus: a longitudinal evaluation of the lipid-lowering effect. Lupus 2012;21(11):1178–82. e. Selzer F, Sutton-Tyrrell K, Fitzgerald S, Tracy R, Kuller L, Manzi S. Vascular stiffness in women with systemic lupus erythematosus.
A Case of Severe Hydroxychloroquine-Induced Retinal ~ We present a case of a 67-year-old female who presented with a twelve-month history of progressive blurred vision in both eyes. The patient was on hydroxychloroquine 200 mg twice a day for eight years for the treatment of scarring alopecia. Two years prior to presenting, the patient was found to have chronic kidney disease stage 3 secondary to hypertension.
Hydroxychloroquine Efficacy in Chronic Urticaria - Full ~ Reeves GE, Boyle MJ, Bonfield J, Dobson P, Loewenthal M. Impact of hydroxychloroquine therapy on chronic urticaria: chronic autoimmune urticaria study and evaluation. Intern Med J. 2004 Apr;34(4):182-6.
Atherosclerosis - Textbook of Cardiology ~ In 2008, heart attack and stroke were responsible for 7.3 million deaths and 6.2 million deaths, respectively. Obstructive coronary and cerebrovascular diseases are caused, in the vast majority of cases, by atherosclerosis. Atherosclerotis vascular disease begins early in life and over time can eventually lead to obstructive arterial disease.
Hydroxychloroquine Reduces Cardiovascular Morbidity Risk ~ Rheumatoid arthritis is a chronic disease that causes pain, stiffness, swelling and limitation in the motion and function of multiple joints. Though joints are the principal body parts affected by .
Arthritis and Use of Hydroxychloroquine Associated with a ~ Hydroxychloroquine is a highly important disease-stabilizing medication for SLE, and its use has been associated with a delayed onset of SLE as well as fewer organ complications 16,17. The pathogenesis of MAS has been increasingly elucidated over the last decade, and is driven in part by the production of IL-1, IL-6 and TNF-alpha 18 .
Hydroxychloroquine for Crohns Disease and Ulcerative ~ Hydroxychloroquine (Plaquenil®) has received little attention in Crohn’s disease (CD). 1 This anti-malarial agent is an older disease-modifying anti-rheumatic drug and is used by rheumatologists for patients who try and fail or fear trying immunomodulator and biologic therapy.
WebMD - Better information. Better health. ~ The leading source for trustworthy and timely health and medical news and information. Providing credible health information, supportive community, and educational services by blending award .
Hydroxychloroquine Causes Severe Vacuolar Myopathy in a ~ Hydroxychloroquine Causes Severe Vacuolar Myopathy in a Patient With Chronic Graft-Versus-Host Disease Javier BolanËœos-Meade,1 Lan Zhou,2 Ahmet Hoke,2 Andrea Corse,2 Georgia Vogelsang,1 and Kathryn R. Wagner2* 1Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland 2 Department of Neurology, The Johns Hopkins Hospital, Baltimore, Maryland A 51-year-old man developed .
Atherosclerosis - Wikipedia ~ Atherosclerosis is a disease in which the inside of an artery narrows due to the buildup of atheromatous plaque. Initially, there are generally no symptoms. When severe, it can result in coronary artery disease, stroke, peripheral artery disease, or kidney problems, depending on which arteries are affected. Symptoms, if they occur, generally do not begin until middle age.