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Ursodeoxycholic acid prevents ventricular conduction slowing and arrhythmia by restoring Ttype calcium current in fetuses during cholestasis
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Ursodeoxycholic acid prevents ventricular conduction ~ Title: Ursodeoxycholic acid prevents ventricular conduction slowing and arrhythmia by restoring T-type calcium current in fetuses during cholestasis
Julia Gorelik's research works / Imperial College London ~ Ursodeoxycholic acid prevents ventricular conduction slowing and arrhythmia by restoring T-type calcium current in fetuses during cholestasis Article Full-text available
Thieme E-Journals - American Journal of Perinatology ~ 12 Adeyemi O, Alvarez-Laviada A, Schultz F. , et al. Ursodeoxycholic acid prevents ventricular conduction slowing and arrhythmia by restoring T-type calcium current in fetuses during cholestasis. PLoS One 2017; 12 (09) e0183167
(PDF) Intrahepatic cholestasis of pregnancy: Observational ~ Ursodeoxycholic acid prevents ventricular conduction slowing and arrhythmia by restoring T-type calcium current in fetuses during cholestasis Article Full-text available
Dexamethasone and ursodeoxycholic acid protect against the ~ Oladipupo Adeyemi, Anita Alvarez-Laviada, Francisca Schultz, Effendi Ibrahim, Michael Trauner, Catherine Williamson, Alexey V. Glukhov, Julia Gorelik, Ursodeoxycholic acid prevents ventricular conduction slowing and arrhythmia by restoring T-type calcium current in fetuses during cholestasis, PLOS ONE, 10.1371/journal.pone.0183167, 12, 9 .
Cav3.2 subunit underlies the functional T-type Ca2 ~ Ursodeoxycholic acid prevents ventricular conduction slowing and arrhythmia by restoring T-type calcium current in fetuses during cholestasis 21 September 2017 / PLOS ONE, Vol. 12, No. 9 Restoring the impaired cardiac calcium homeostasis and cardiac function in iron overload rats by the combined deferiprone and N-acetyl cysteine
Ursodeoxycholic acid — adverse effects and drug ~ Introduction. The dihydroxy bile acid, ursodeoxycholic acid (UDCA), is increasingly being used for the treatment of chronic cholestatic liver diseases, and its pharmacodynamic effects have been reviewed in detail recently. 1-5 UDCA was identified as a major constituent of dried bile of the Chinese black bear 75 years ago, 6 and has been used for centuries in Chinese medicine. 7 Beneficial .
Ursodeoxycholic acid for the prevention of hepatic ~ Ursodeoxycholic acid (UDCA) is a hydrophilic bile acid that constitutes less than 5% of bile acids in normal bile.3 This proportion can be increased to 40% to 50% by oral administration.3 The concentration of hydrophobic bile acids is thereby reduced.4-6 Hydrophobic bile acids are toxic to liver parenchymal cells in direct contact, which takes place in disorders damaging bile ducts, whereas .
Improved Survival with Ursodeoxycholic Acid Prophylaxis in ~ The survival difference seen at 1 year in favor of the UDCA-treated group (71% versus 55%) remained similar in the long-term follow-up. At 10 years, 48% of patients given UDCA and 38% of control patients were alive (P = .037, adjusted for multiple testing .047) (Figure 1A).The survival difference was marked among the low-risk patients, 63% versus 46%, P = .019 (adjusted .038) (Figure 1B .
Sex and cardiac electrophysiology: fetal arrhythmia in ~ O. Adeyemi, A. Alvarez-Laviada, F. Schultz, E. Ibrahim, M. Trauner, C. Williamson, et al.Ursodeoxycholic acid prevents ventricular conduction slowing and arrhythmia by restoring T-type calcium current in fetuses during cholestasis
Ursodeoxycholic acid inhibits uptake and vasoconstrictor ~ Intrahepatic cholestasis of pregnancy (ICP) is a disease characterized by elevated maternal and fetal plasma bile acids, which may have severe short-term and long-term consequences for the fetus (1, 2).Although maternal prognosis is good, ICP poses significant risks, including fetal distress, preterm delivery, and, in severe cases, spontaneous fetal death ().
Failure of ursodeoxycholic acid to prevent a cholestatic ~ Ursodeoxycholic acid was administered to a patient with benign recurrent intrahepatic cholestasis to prevent cholestatic episodes. A detailed study of bile acid metabolism in this patient was carried out in the anicteric and icteric phases before and after ursodeoxycholic acid (750 mg/day) administration.
Use of ursodeoxycholic acid in liver diseases - Kumar ~ Ursodeoxycholic acid has been reported to improve clinical symptoms and biochemical markers of cholestasis in a dose of 15 mg/kg day in patients with progressive familial intrahepatic cholestasis (Byler's disease), 137 biliary atresia, 138, 139 and total parenteral nutrition (TPN)‐associated liver disease. 140, 141 Larger trials are required .
Ursodeoxycholic acid versus placebo in women with ~ Ursodeoxycholic acid is a naturally occurring bile acid that is present in small amounts in humans. It has several actions that result in the improvement of cholestasis, including increasing biliary bile acid excretion through upregulation of hepatic metabolising enzymes and bile acid transporters, stimulation of impaired hepatocellular secretion by post-transcriptional mechanisms .
Ursodeoxycholic Acid - Uses, Side Effects, Substitutes ~ Ursodeoxycholic Acid is a bile acid which is used to treat gallstone problems. Gallstones can result in symptoms like jaundice, pain, inflammation of the pancreas and gallbladder too. The gall bladder creates stones when bile (generally a liquid) hardens. Calcium deposits in the gallbladder can also .
Ursodeoxycholic acid 150mg Tablets - Summary of Product ~ The dosage of ursodeoxycholic acid in primary biliary cholangitis (stages I-III), amounts to 12-15 mg/kg/day, which is equivalent to four to eight tablets of 150 mg, two to four tablets of 300 mg, to be taken in two to three portions during the day, or with two tablets of 450 mg, to be taken in two portions during the day.
Ursodeoxycholic acid - Wikipedia ~ Ursodeoxycholic acid (UDCA), also known as ursodiol, is a secondary bile acid, produced in humans and most other species from metabolism by intestinal bacteria.It is synthesized in the liver in some species, and was first identified in bear bile, which is the derivation of its name Ursus.In purified form, it has been used to treat or prevent several diseases of the liver or bile ducts.
Ursodiol for Primary Sclerosing Cholangitis / NEJM ~ Ursodiol (ursodeoxycholic acid) is beneficial for patients with primary biliary cirrhosis, another cholestatic liver disease that has some features in common with primary sclerosing cholangitis .
EP0088637A2 - A method for producing ursodeoxycholic acid ~ ursodeoxycholic acid acid microorganism producing lithocholic Prior art date 1982-03-09 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Granted Application number EP83301303A Other languages German (de)
Comparison of the arrhythmogenic effects of tauro‐ and ~ Oladipupo Adeyemi, Anita Alvarez-Laviada, Francisca Schultz, Effendi Ibrahim, Michael Trauner, Catherine Williamson, Alexey V. Glukhov, Julia Gorelik, Ursodeoxycholic acid prevents ventricular conduction slowing and arrhythmia by restoring T-type calcium current in fetuses during cholestasis, PLOS ONE, 10.1371/journal.pone.0183167, 12, 9 .
Beneficial Effect of Ursodeoxycholic Acid on High Glucose ~ ursodeoxycholic acid (UDCA) is an endogenous secondary bile acid recently implicated in the genesis of cardiac arrhythmias when present at low concentration in human serum [1]. The present study was aimed to investigate for the first time the use of UDCA as novel therapeutic option in preventing the high glucose-induced long QT interval
Efficacy of Ursodeoxycholic Acid in Treating Intrahepatic ~ Ursodeoxycholic acid in the treatment of cholestasis of pregnancy: a randomized, double-blind study controlled with placebo. J Hepatol. 1997; 27 : 1022-1028 Abstract
Ursodeoxycholic acid for the treatment of intrahepatic ~ Ursodeoxycholic acid was associated with a decrease in bile acids in most patients (p = 0.16) and with a significant decrease in serum transaminases (p = 0.03). CONCLUSIONS: Ursodeoxycholic acid is an effective therapy for relief of pruritus and improvement of the liver dysfunction that occurs with intrahepatic cholestasis of pregnancy.
Search Results - ( "Ursodeoxycholic acid" ) - National ~ Ursodeoxycholic acid is a naturally occurring bile acid which is taken as either a tablet or liquid to try and prevent liver disease in people with cystic fibrosis. The best response seems to be from a total dose of 20 mg/kg/day in two to three separate doses and given initially for several months but possibly indefinitely.