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Identification of Therapeutic Candidates for Chronic Lymphocytic Leukemia from a Library of Approved Drugs
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Identification of Therapeutic Candidates for Chronic ~ Identification of Therapeutic Candidates for Chronic Lymphocytic Leukemia from a Library of Approved Drugs Min Shen , 1, * Yaqin Zhang , 1 Nakhle Saba , 2 Christopher P. Austin , 1 Adrian Wiestner , 2 and Douglas S. Auld 1, *
Identification of therapeutic candidates for chronic ~ To our knowledge, this is the first study to screen a drug library against primary CLL cells to identify candidate agents for anti-cancer therapy. The results presented here offer possibilities for the development of novel drug candidates for therapeutic uses to treat CLL and other diseases.
Identification of Therapeutic Candidates for Chronic ~ Chronic lymphocytic leukemia (CLL) is an adult lymphoid malignancy with a variable clinical course. There is considerable interest in the identification of new treatments, as most current approaches are not curative. While most patients respond to initial chemotherapy, relapsed disease is often resistant to the drugs commonly used in CLL and patients are left with limited therapeutic options.
Identification of Therapeutic Candidates for Chronic ~ Identification of Therapeutic Candidates for Chronic Lymphocytic Leukemia from a Library of Approved Drugs By Min Shen, Yaqin Zhang, Nakhle Saba, Christopher P. Austin, Adrian Wiestner and Douglas S. Auld
Correction: Identification of Therapeutic Candidates for ~ This corrects the article "Identification of Therapeutic Candidates for Chronic Lymphocytic Leukemia from a Library of Approved Drugs" in volume 8, e75252. There were errors in Figures 2-6. Correct versions of these figures are available below.
The NCATS Pharmaceutical Collection: a 10-year update ~ M. Shen, et al.Identification of therapeutic candidates for chronic lymphocytic leukemia from a library of approved drugs PLoS One, 8 (2013), Article e75252 Google Scholar
Min Shen's research works / National Center for Advancing ~ Chronic lymphocytic leukemia (CLL) is an adult lymphoid malignancy with a variable clinical course. There is considerable interest in the identification of new treatments, as most current .
Treating Acute Lymphocytic Leukemia (ALL) ~ Targeted Therapy for Acute Lymphocytic Leukemia (ALL) . Chemotherapy (chemo)2 is the use of drugs to treat cancer. Chemo drugs travel through the bloodstream to reach cancer cells all over the body. This makes chemo useful for cancers such as leukemia that has spread throughout the body.
Chemotherapy and Drug Therapy / Leukemia and Lymphoma Society ~ The order of which of these targeted therapies to use as first, second and third treatment will be determined by future clinical trials. Additionally, drugs approved for other blood cancers, such as lenalidomide (Revlimid®) or Acalabrutinib (Calquence®), are used in CLL in some cases in controlled clinical trials. Monoclonal Antibody Therapies
Chronic lymphocytic leukemia - Diagnosis and treatment ~ Tests and procedures used to diagnose chronic lymphocytic leukemia include blood tests designed to: Count the number of cells in a blood sample. A complete blood count may be used to count the number of lymphocytes in a blood sample. A high number of B cells, one type of lymphocyte, may indicate chronic lymphocytic leukemia.
Three Newly Approved Drugs for Chronic Lymphocytic ~ Three agents have received Food and Drug Administration (FDA) approval for treatment of chronic lymphocytic leukemia (CLL) within the past year. Ibrutinib and idelalisib block B-cell receptor signaling through inhibition of Bruton tyrosine kinase and phosphatidylinositol 3-kinase δ molecules respectively, interfering with several pathways required for leukemia cell survival.
Clinical Trials / Leukemia and Lymphoma Society ~ Taking part in a clinical trial may be the best treatment choice for some chronic lymphocytic leukemia (CLL) patients. Clinical trials are under way to improve remission rates for CLL. Today's standard treatments for cancer are based on earlier clinical trials. The Leukemia & Lymphoma Society continues to invest funds in CLL research.
Chronic lymphocytic leukemia - Wikipedia ~ Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). Early on there are typically no symptoms. Later non-painful lymph node swelling, feeling tired, fever, night sweats, or weight loss for no clear reason may occur. Enlargement of the spleen and low red blood cells (anemia) may also occur.
Chronic lymphocytic leukemia: 2017 - Wiley Online Library ~ United States, chronic lymphocytic leukemia (CLL) is the most common type of leukemia in western countries. More than 15 000 newly diag-nosed cases and approximately 4500 deaths are currently estimated.1,2 The median age at diagnosis lies between 67 and 72 years. More male than female patients (1.7:1) are affected.3–5 As the incidence rate rises
Treating Chronic Lymphocytic Leukemia ~ Treating Chronic Lymphocytic Leukemia cancer / 1.800.227.2345 Main treatments Because CLL often grows slowly, not everyone needs to be treated right away. When treatment is needed, the main treatments used are: Chemotherapy for Chronic Lymphocytic Leukemia Monoclonal Antibodies for Chronic Lymphocytic Leukemia
Staff Profile: Min Shen / National Center for Advancing ~ Identification of therapeutic candidates for chronic lymphocytic leukemia from a library of approved drugs; Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS
Incidental Richter transformation in chronic lymphocytic ~ Incidental Richter transformation in chronic lymphocytic leukemia patients during temporary interruption of ibrutinib . a Bruton tyrosine kinase inhibitor approved for treatment of patients with chronic lymphocytic leukemia (CLL), is administered as continuous therapy until unacceptable toxicity or disease progression.
Douglas AULD / Sr. Investigator / Ph.D. / Novartis ~ Chronic lymphocytic leukemia (CLL) is an adult lymphoid malignancy with a variable clinical course. There is considerable interest in the identification of new treatments, as most current .
Systematic identification of personal tumor-specific ~ We focused on chronic lymphocytic leukemia (CLL), a common adult B-cell malignancy that remains largely incurable but is potentially immune responsive based on reports of its spontaneous regression and susceptibility to the graft-versus-leukemia effect. 22-24 We predicted candidate leukemia neoantigens from CLL DNA sequencing data 25,26 and .
Chronic Leukemias / Pharmacotherapy: A Pathophysiologic ~ The chronic leukemias include chronic myeloid leukemia (CML), chronic lymphocytic leukemia (CLL), hairy cell leukemia, and prolymphocytic leukemia. The typical clinical presentation of the chronic leukemias is an indolent course in contrast to patients with acute leukemia who will die of their disease within weeks to months if not treated. .
Hematologic Disorders / CURRENT Practice Guidelines in ~ In patients with myeloma, non-Hodgkin lymphoma, or chronic lymphocytic leukemia (CLL), clinicians should observe the hematologic response to cancer treatment before considering an ESA. Counsel patients on the thromboembolic risks associated with ESAs prior to initiation.
Novel Treatments of Special Cases in Chronic Lymphocytic ~ John C. Byrd, MD, the D. Warren Brown Chair of Leukemia Research and director, Division of Hematology at The Ohio State University, recently spoke at the American Society of Hematology’s inaugural meeting on Hematologic Malignancies in Chicago about novel agents in treating chronic lymphocytic leukemia (CLL).
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