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Characterization of broadly neutralizing antibody responses to HIV1 in a cohort of long term nonprogressors
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Characterization of broadly neutralizing antibody ~ Characterization of broadly neutralizing antibody responses to HIV-1 in a cohort of long term non-progressors. Nuria González, . it is possible that long-term nonprogressors (LTNPs), individuals with low levels of viremia who maintain stable CD4 T cell counts over 10 years of infection, develop neutralizing antibodies with a high affinity .
Characterization of broadly neutralizing antibody ~ Background Only a small fraction of HIV-1-infected patients develop broadly neutralizing antibodies (bNAbs), a process generally associated to chronic antigen stimulation. It has been described that rare aviremic HIV-1-infected patients can generate bNAbs but this issue remains controversial. To address this matter we have assessed bNAb responses in a large cohort of long-term non-progressors .
Characterization of broadly neutralizing antibody ~ Characterization of broadly neutralizing antibody responses to HIV-1 in a cohort of long term non-progressors By Nuria Gonzalez-Fernandez, Krisha McKee, Rebecca M Lynch, Ivelin S Georgiev, Laura Jimenez, Eulalia Grau, Maria Eloisa Yuste-Herranz, Peter D Kwong, John R Mascola and Jose Alcami
(PDF) Broadly neutralizing antibodies in HIV-1 treatment ~ Antibodies that naturally develop in some individuals infected with human immunodeficiency virus 1 (HIV-1) and are capable of broadly neutralizing diverse strains of HIV-1 are useful for two .
(PDF) Broadly Cross-Neutralizing Antibodies in HIV-1 ~ Preventive HIV-1 vaccine strategies rely on the elicitation of broadly neutralizing antibody (bNAb) responses, but their induction in vivo by vaccination remains challenging.
Broadly Neutralizing Antibody Responses in a Subset of HIV ~ Identification of broadly neutralizing antibodies (NAbs) generated during the course of HIV-1 infection is essential for effective HIV-1 vaccine design. The magnitude and breadth of neutralizing activity in the sera from 46 antiretroviral treatment–naive HIV-1 clade C-infected individuals was measured in a single round infection assay using .
Broadly Neutralizing Antibody Responses in a Large ~ Author Summary Understanding how HIV-1-broadly neutralizing antibodies (bnAbs) develop during natural infection is essential to the design of an efficient HIV vaccine. We studied kinetics and correlates of neutralization breadth in a large sub-Saharan African longitudinal cohort of 439 participants with primary HIV-1 infection. Broadly nAb responses developed in 15% of individuals, on average .
Characteristics of the Earliest Cross- Neutralizing ~ Here we analyzed the cross-neutralizing antibody responses in longitudinal plasmas collected soon after and up to seven years after HIV-1 infection. We find that anti-HIV-1 cross-neutralizing antibody responses first become evident on average at 2.5 years and, in rare cases, as early as 1 year following infection.
Immunological Fingerprints of Controllers Developing ~ Characterization of broadly neutralizing antibody responses to HIV-1 in a cohort of long term non-progressors. PLoS One. 2018; 13 : e0193773 View in Article
HIV therapy by a combination of broadly neutralizing ~ Human antibodies to HIV-1 can neutralize a broad range of viral isolates in vitro and protect non-human primates against infection 1,2.Previous work showed that antibodies exert selective pressure on the virus but escape variants emerge within a short period of time 3,4.However, these experiments were performed before the recent discovery of more potent anti-HIV-1 antibodies and their .
Neutralizing Antibody Responses to HIV-1 Infection ~ Neutralizing antibody responses were examined by two independently executed neutralization assays: the first one was a single round infection neutralization assay against a panel of 10 primary HIV .
(PDF) Impact of HIV-1 Diversity on Its Sensitivity to ~ Sensitivity to Broadly Neutralizing Antibodies of Recently Transmitted HIV-1 Clade CRF02_AG Viruses with a Focus on Evolution over T ime. J. Virol. 2019 , 93 , e01492-18.
Broadly Neutralizing Antibodies for HIV-1 Prevention or ~ High serum titers of neutralizing antibodies develop in a small fraction of people who become infected with HIV-1. Isolation of such broadly neutralizing antibodies (bNAbs) has led to a new and pro.
HIV-1 resistance to neutralizing antibodies: Determination ~ 1. Introduction. During human immunodeficiency virus type 1 (HIV-1) infection, the neutralizing antibody response directed against the viral envelope (Env) proteins gp120 and gp41 co-evolves with the viral quasispecies (Frost et al., 2005, Overbaugh and Morris, 2012, Wibmer et al., 2013).In natural infection and antibody-based treatment, viral escape occurs even against the most potent broadly .
Detection of Broadly Neutralizing Activity within the ~ While it has been described that early cross-neutralizing antibody responses (on average, at 2.5 years after infection) targeted mainly epitopes within and around the CD4-binding site or epitopes present on the virion-associated trimeric envelope but not glycopeptide residues in the V1/V2 region , early development of broadly neutralizing .
The Neutralizing Antibody Response in an Individual with ~ The effect of serial HIV-1 infection on the development of the broadly neutralizing antibody (bNAb) response was studied in an individual, H01-10366, with a serial HIV-1 superinfection (SI), hence .
Aiming to induce broadly reactive neutralizing antibody ~ Status of neutralizing antibody responses that are induced with current HIV-1 immunogens. Current efforts to elicit effective antibody responses against HIV-1 are focused on the need to generate broadly neutralizing antibodies against a wide spectrum of primary isolates. This is an ambitious goal that has proven to be an enormous scientific .
Neutralizing and other antiviral antibodies in HIV-1 ~ Neutralizing antibodies in HIV-1 infection. Previous studies in HIV-1-infected patients who were treated with highly active antiretroviral therapy suggested that a threshold level of viremia is needed to drive NAb production [10,11].In support of this, low levels of NAbs were seen in a distinct subset of long-term non-progressors (‘elite suppressors’) who maintained viral loads of less .
Frequency and Phenotype of Human Immunodeficiency Virus ~ Induction of broadly cross-reactive neutralizing antibodies (NAb) is an important goal for a prophylactic human immunodeficiency virus type 1 (HIV-1) vaccine. Some HIV-infected patients make a NAb response that reacts with diverse strains of HIV-1, but most candidate vaccines have induced NAb only against a subset of highly sensitive isolates.
Increased breadth of HIV-1 neutralization achieved by ~ Broadly neutralizing antibodies (bNAbs) are rarely elicited by current human immunodeficiency virus type 1 (HIV-1) vaccine designs, but the presence of bNAbs in naturally infected individuals may be associated with high plasma viral loads, suggesting that the magnitude, duration, and diversity of viral exposure may contribute to the development of bNAbs.
Antibody-mediated prevention and treatment of HIV-1 ~ Novel broadly neutralizing antibodies targeting HIV-1 hold promise for their use in the prevention and treatment of HIV-1 infection. Pre-clinical results have encouraged the evaluation of these antibodies in healthy and HIV-1-infected humans. In first clinical trials, highly potent broadly neutralizing antibodies have demonstrated their safety and significant antiviral activity by reducing .
Development of broadly neutralizing antibodies in HIV-1 ~ Broadly neutralizing antibodies (bNAbs), able to prevent viral entry by diverse global viruses, are a major focus of HIV vaccine design, with data from animal studies confirming their ability to prevent HIV infection. However, traditional vaccine approaches have failed to elicit these types of antibodies. During chronic HIV infection, a subset of individuals develops bNAbs, some of which are .
Association of circulatory Tfh-like cells with ~ INTRODUCTION. Neutralizing antibodies are the principal correlates of protection for most licensed preventive vaccines (Leo, Cunningham and Stern 2011).Generation of broadly neutralizing antibodies (bNAbs) by B-cells requires specialized CD4+ T-cells called T-follicular helper (Tfh) cells, which are critical for the priming of B-cell responses in lymph node germinal centers (GC), thus leading .
Discordant memory B cell and circulating anti-Env antibody ~ Long-lived memory B cells (BMem) provide an archive of historic Ab responses. By contrast, circulating Abs typically decline once the immunogen is cleared. Consequently, circulating Abs can underestimate the nature of cognate humoral immunity. On the other hand, the BMem pool should provide a comprehensive picture of Ab specificities that arise over the entire course of infection.
HIV-1 escapes from N332-directed antibody neutralization ~ Current HIV-1 immunogens are unable to induce antibodies that can neutralize a broad range of HIV-1 (broadly neutralizing antibodies; bNAbs). However, such antibodies are elicited in 10–30 % of HIV-1 infected individuals, and the co-evolution of the virus and the humoral immune responses in these individuals has attracted attention, because they can provide clues for vaccine design.