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Acute effects of insulin on circulating natriuretic peptide levels in humans
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Acute Metabolic Influences on the Natriuretic Peptide ~ Results: We observed a 27% reduction in the levels of circulating NT-proANP (p < 0.001, maximal at 6 h) after carbohydrate challenge, with no effect on NT-proBNP levels in our human subjects. Glucose treatment of hESC-CMs for 6 h and 24 h increased levels of the primary transcript of miR-425 (pri-miR-425) and mature miR-425.
Effect of insulin on natriuretic peptide gene expression ~ In this study, we examined whether insulin affects the cardiac atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) gene expression and release of proANP-derived peptides in pigs. Anaesthetized pigs were included in an experimental study comparing the effect of hyperinsulinemia in 15 pigs submitted to two different protocols .
Acute Metabolic Influences on the Natriuretic Peptide ~ Acute increases in blood glucose decrease circulating levels of NT-proANP in both lean and overweight or obese individuals, though obese people generally have lower ANP levels at baseline. The beneficial effects of ANP, which include reducing blood pressure and preventing myocardial hypertrophy, may explain the advantages to over-weight and .
Serpil Muge Deger's research works / Vanderbilt University ~ Download full-text. Acute effects of insulin on circulating natriuretic peptide levels in humans. Article. Full-text available. . Acute effects of insulin on circulating natriuretic peptide .
The effect of insulin administration on c-peptide in ~ In critically ill patients with permissive hyperglycemia, it is uncertain whether exogenous insulin administration suppresses or enhances c-peptide secretion (a marker of pancreatic beta-cell response). We aimed to explore this effect in patients with type 2 diabetes. We prospectively enrolled a cohort of 45 critically ill patients with type 2 diabetes managed according to a liberal glucose .
T Wasada's research works / Tokyo Women's Medical ~ Reference: Acute effects of insulin on circulating natriuretic peptide levels in humans Effects of acute hyperinsulinemia on plasma atrial and brain natriuretic peptide concentrations Citing article
Increase in circulating insulin induced by atrial ~ To search for possible metabolic interactions of alpha-human-atrial natriuretic peptide (alpha hANP), we evaluated in 20 normal subjects blood levels of alpha hANP, glucose, insulin, cortisol, electrolytes, catecholamines, free fatty acids, carnitine and amino acids, blood pressure (BP), and heart rate before, during, and after a 45-min .
Insulin Up-Regulates Natriuretic Peptide Clearance ~ Regulation of NPR-mRNA expression and circulating levels of NP by insulin and simultaneous effects of high insulin and high glucose in the clamp experiments In the steady state of the hyperinsulinemic-hyperglycemic clamp experiments, circulating insulin levels increased to 754.4 ± 321.7 pmol/liter and were higher as in the hyperinsulinemic .
Serum proatrial natriuretic peptide concentrations during ~ 1. Introduction. Atrial natriuretic peptide (ANP) is well known for its natriuretic, diuretic and vasodilatory properties, and plays an important role in the regulation of blood volume and blood pressure [].Obese individuals have low circulating concentrations of proANP fragments, which are stable markers of ANP secretion, and it has been proposed that this natriuretic peptide deficiency could .
Inflammation and Circulating Natriuretic Peptide Levels ~ Methods: The associations between inflammation and NP levels were examined in 3 independent studies. First, in 5481 MESA (Multi-Ethnic Study of Atherosclerosis) participants, the cross-sectional (exam 1) and longitudinal (exams 1 to 3) associations between circulating IL6 (interleukin-6) and NT-proBNP (N terminal pro B-type natriuretic peptide) levels were examined in multivariable-adjusted .
Acute Metabolic Influences on the Natriuretic Peptide ~ Background The cardiac natriuretic peptides (NPs), atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), have central roles in sodium and blood pressure regulation. Extracardiac factors (e.g., obesity and diabetes) influence NP production, potentially altering cardiovascular responses to volume and pressure stress. Objectives This study examined the effects of acute .
Natriuretic Peptides, Heart, and Adipose Tissue: New ~ Natriuretic peptides (NPs) play a key role in cardiovascular homeostasis, counteracting the deleterious effects of volume and pressure overload and activating antibrotic and antihypertrophic pathways in the heart. N-terminal B-type NP (NT-proBNP) also is a promising biomarker of global cardiovascular risk in the general population, and there is increasing interest on its potential use in .
Liraglutide Promotes Natriuresis but Does Not Increase ~ OBJECTIVE GLP-1 receptor (GLP-1R) agonists induce natriuresis and reduce blood pressure (BP) through incompletely understood mechanisms. We examined the effects of acute and 21-day administration of liraglutide on plasma atrial natriuretic peptide (ANP), urinary sodium excretion, office and 24-h BP, and heart rate (HR). RESEARCH DESIGN AND METHODS Liraglutide or placebo was administered for 3 .
Defective Natriuretic Peptide Receptor Signaling in ~ Circulating natriuretic peptide (NP) levels are reduced in obesity and predict the risk of type 2 diabetes (T2D). Since skeletal muscle was recently shown as a key target tissue of NP, we aimed to investigate muscle NP receptor (NPR) expression in the context of obesity and T2D. Muscle NPRA correlated positively with whole-body insulin sensitivity in humans and was strikingly downregulated in .
The renal and cardiovascular effects of natriuretic ~ Natriuretic peptide receptor C as a clearance receptor. In 1987, Maack et al. reported that they injected C-ANP (4–23), a ring-depleted analog of ANP, into isolated perfused rat kidney and detected no renal effects, although C-ANP (4–23) binds to 99% of the receptors there.When they injected C-ANP (4–23) into the intact anesthetized rats, the rats responded with markedly increased plasma .
Plasma Level of B-Type Natriuretic Peptide as a Prognostic ~ B-type natriuretic peptide (BNP) is a cardiac hormone that is secreted mainly from the ventricles; it has many biological effects, including vasodilation, natriuresis, and inhibition of both the rennin-angiotensin and sympathetic nervous systems. 1–7 BNP is secreted from the failing heart into the systemic circulation; the plasma level of this peptide is elevated in patients with heart .
Cardiovascular and metabolic effects of 48-h glucagon-like ~ GLP-1 infusion increased circulating insulin levels and reduced plasma glucose levels and resulted in hypoglycemia in eight patients. Some in vitro and animal studies indicate an immediate insulin sensitizing effect, but we could not confirm this effect in these patients. On the contrary, HOMA-IR tended to increase during GLP-1.
Protective effect of lyophilized recombinant human brain ~ Brain natriuretic peptide (BNP) has a protective effect on acute injury of the heart, brain, and lung. However, its role in acute kidney injury (AKI) remains unclear. The aim of this study was to investigate the effect of lyophilized recombinant human BNP (lrh-BNP) on AKI and the underlying molecular mechanisms.
Atrial natriuretic peptide - Wikipedia ~ Atrial natriuretic peptide (ANP) or atrial natriuretic factor (ANF) is a natriuretic peptide hormone secreted from the cardiac atria that in humans is encoded by the NPPA gene. Natriuretic peptides (ANP, BNP, and CNP) are a family of hormone/paracrine factors that are structurally related. The main function of ANP is causing a reduction in expanded extracellular fluid (ECF) volume by .
role of natriuretic peptides in cardioprotection ~ Thus, the natriuretic peptide system consists of three ligands and three receptors. These peptides cause effects such as diuresis, natriuresis, vasodilation, and inhibition of aldosterone synthesis and renin secretion as a circulating hormone, and thereby play an important role in regulating blood pressure and blood volume ().The intensity of actions differs among the three peptides.
Racial/ethnic differences in circulating natriuretic ~ Natriuretic peptides are cardiac-derived hormones that enhance insulin sensitivity and reduce fat accumulation. Low natriuretic peptide levels are associated with increased risk of type 2 diabetes mellitus (DM2); a condition with variable prevalence across racial/ethnic groups. Few studies have examined whether circulating natriuretic peptide levels and their response to preventive .
Exercise and metabolic health: beyond skeletal muscle ~ In the following sections, we discuss the acute (Fig. 1) and chronic (Fig. 2) effects of exercise on each of the peripheral organs involved in the regulation of whole-body insulin sensitivity and metabolic health, and the associated systemic health effects.Unless otherwise specified, only data from human studies are presented. A growing body of work implicates hundreds or even thousands of .
B-Type Natriuretic Peptide Prevents Acute Hypertrophic ~ It is unknown if similar antihypertrophic natriuretic peptide effects are evident in whole hearts or if these are affected by chronically elevated glucose levels. In vivo, natriuretic peptide bioactivity is limited by neutral endopeptidase–mediated hydrolysis ( 13 ), and inhibition of neutral endopeptidase attenuates cardiac hypertrophy and .
Role of the Natriuretic Peptide System in Cardiorenal ~ Brain natriuretic peptide, although originally isolated from the porcine brain, is synthesized primarily in ventricular cardiomyocytes in response to ventricular pressure or volume stress. 35 Its physiological effects are similar to those of ANP, and it becomes the major circulating natriuretic peptide during long-term volume expansion in .