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Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States
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Variations in Glycogen Synthesis in Human Pluripotent Stem ~ Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States Richard J. Chen , 1 Guofeng Zhang , 1 Susan H. Garfield , 2 Yi-Jun Shi , 3 Kevin G. Chen , 3 Pamela G. Robey , 4 and Richard D. Leapman 1, *
Variations in Glycogen Synthesis in Human Pluripotent Stem ~ Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States Article (PDF Available) in PLoS ONE 10(11):e0142554 · November 2015 with 593 Reads
Variations in Glycogen Synthesis in Human Pluripotent Stem ~ We further confirmed glycogen variations under different naïve pluripotent cell growth conditions based on the addition of the GSK-3 inhibitor BIO. Our data suggest that primed hPSCs treated with naïve growth conditions acquire altered pluripotent states, similar to those naïve-like hPSCs, with increased glycogen synthesis.
Variations in Glycogen Synthesis in Human Pluripotent Stem ~ Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States By Chen Richard J., Zhang Guofeng, Garfield Susan H., Shi Yi-Jun, Chen Kevin G., Robey Pamela G. and Leapman Richard D.
A single-cell Raman-based platform to identify ~ We developed a label-free and noninvasive single-cell Raman microspectroscopy (SCRM)-based platform to identify neural cell lineages derived from clinically relevant human induced pluripotent stem cells (hiPSCs). Through large-scale Raman spectral analysis, we can distinguish hiPSCs and hiPSC-derived neural cells using their intrinsic biochemical profile.
Transformation to Inducible Pluripotent Stem Cells ~ N. Sun, et al.Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells Proc Natl Acad Sci USA, 106 (37) (2009), pp. 15720-15725 Google Scholar
Single Cell RNA-Sequencing of Pluripotent States Unlocks ~ Here, we performed single cell RNA-sequencing of mESCs cultured in serum/LIF, 2i/LIF, and the alternative ground state, a2i/LIF. This approach allowed us to compare the subpopulation structures and provide a deep characterization of cell-to-cell variation in gene expression levels across these three pluripotent states.
Glycome Diagnosis of Human Induced Pluripotent Stem Cells ~ Recently, synthetic substrates recognizing cell surface glycans were reported to facilitate the long term culture of pluripotent stem cells . Thus, global analysis of the cellular glycomes of iPSCs and ESCs performed in this study will be necessary to provide the basis to explore the functions and applications of the stem cell glycobiology.
Regulatory Principles of Pluripotency - Cell Stem Cell ~ Pluripotency is the remarkable capacity of a single cell to engender all the specialized cell types of an adult organism. This property can be captured indefinitely through derivation of self-renewing embryonic stem cells (ESCs), which represent an invaluable platform to investigate cell fate decisions and disease.
Naive Pluripotent Stem Cells Derived Directly from ~ In this paper, Nichols, Smith, and colleagues show that stem cells can be derived from human embryos by dissociation of the inner cell mass into single cells and culture in conditions that suppress further differentiation. Molecular profiling indicates a more naive status than previously observed for human embryonic stem cell lines.
Post-Transcriptional Regulation of - Cell Stem Cell ~ Signer et al. discuss how post-transcriptional mechanisms, including RNA modifications and proteostasis, influence stem cell identity and function. They also examine how defects in these post-transcriptional mechanisms deregulate tissue-specific stem cells and progenitors in human disease and stress conditions and discuss their potential as both diagnostic and therapeutic targets.
Glycogen synthase kinase-3 inhibition sensitizes human ~ 1. Introduction. Since the first successful reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) (Takahashi and Yamanaka, 2006), countless efforts have been made to fully explore the potential applications of iPSCs in biomedical research and remarkable progress has been made.Human iPSCs hold great promise in personalized disease modeling and drug screening, and could .
Advances in Pluripotent Stem Cells: History, Mechanisms ~ Thus, VSELs, as a pluripotent stem cell, may hold a potential advantage of being able to differentiate across germ layers in adult animals or human subjects. Such cells may function as an alternative to monopotent tissue-committed stem cells in adults . In addition, VSELs may overcome several problems of ESCs (ethical controversies) and iPSCs .
Induced Pluripotent Stem Cells - ScienceDirect ~ In cell-cell fusion experiments, the somatic cell nuclei can be reset to a state of pluripotency when fused with pluripotent stem cells such as embryonic carcinoma cells, ESCs, and embryonic germ cells . This pointed to the existence of additional factors that can facilitate reprogramming.
Techniques of Human Embryonic Stem Cell and Induced ~ Developing procedures for the derivation of human pluripotent stem cells (PSCs) gave rise to novel pathways into regenerative medicine research. For many years, stem cells have attracted attention as a potentially unlimited cell source for cellular therapy in neurodegenerative disorders, cardiovascular diseases, and spinal cord injuries, for example. In these studies, adult stem cells were .
Naive embryonic stem cells: The future of stem cell research? ~ Our results indicate that there is a high level of glycogen synthesis (0.28 to 0.62 μg/μg proteins) in undifferentiated human embryonic stem cells (hESCs) compared with the glycogen levels (0 to .
MicroRNA Profiling of Human-Induced Pluripotent Stem Cells ~ Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States 13 November 2015 / PLOS ONE, Vol. 10, No. 11 SOX2 and SOX2-MYC Reprogramming Process of Fibroblasts to the Neural Stem Cells Compromised by Senescence
Pluripotent stem cell-derived hepatocyte-like cells ~ Human embryonic stem (hES) cell- and induced pluripotent stem (iPS) cell-derived hepatocyte-like cells may enable cell based therapeutics, the study of the mechanisms of human disease and human development, and provide a platform for screening the efficacy and toxicity of pharmaceuticals. iPS cells can be differentiated in a step-wise fashion .
Transcriptional Heterogeneity in Naive and Primed Human ~ Conventional human embryonic stem cells are considered to be primed pluripotent but can be induced to enter a naive state. However, the transcriptional features associated with naive and primed .
Single Cell RNA-Sequencing of Pluripotent States Unlocks ~ Our molecular understanding of the divergent pluripotent states, however, remains quite limited. Single cell RNA-sequencing technology is increasingly used to deconstruct heterogeneous populations, lineage trajectories, and determinants of cell fate, questions that are central to the stem cell field (Etzrodt et al., 2014).
(PDF) A Liver Model of Infantile-Onset Pompe Disease Using ~ However, the in vitro directed differentiation of human pluripotent stem cells into mature hepatocytes remains challenging. Little attention has so far been paid to variations among hiPSC lines in .
Pluripotent genes in avian stem cells / Request PDF ~ Human and mouse embryonic stem cells (ESCs) are derived from blastocyst-stage embryos but have very different biological properties, and molecular analyses suggest that the pluripotent state of .
Patient and Disease–Specific Induced Pluripotent Stem ~ Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production of limitless supply of patient-specific somatic cells that enable advancement in cardiovascular precision medicine. Over the past decade, researchers have developed protocols to differentiate iPSCs to multiple .
Publications / Richard J. Chen ~ Richard Chen, Filip Jankovic, Nikki Marinsek, Luca Foschini, Lampros Kourtis, Alessio Signorini, Melissa Pugh, Jie Shen, Roy Yaari, Vera Maljkovic, and others. 2019.“ Developing Measures of Cognitive Impairment in the Real World from Consumer-Grade Multimodal Sensor Streams.”In Proceedings of the 25th ACM SIGKDD International Conference on Knowledge Discovery & Data Mining, Pp. 2145–2155.