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A Snapshot of the Hepatic Transcriptome Ad Libitum Alcohol Intake Suppresses Expression of Cholesterol Synthesis Genes in AlcoholPreferring P Rats
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A Snapshot of the Hepatic Transcriptome: Ad Libitum ~ A Snapshot of the Hepatic Transcriptome: Ad Libitum Alcohol Intake Suppresses Expression of Cholesterol Synthesis Genes in Alcohol-Preferring (P) Rats. . However, it is well established that down-regulation of hepatic cholesterol synthesis genes, as can be achieved by the use of statins, can consistently suppress plasma LDL and raise .
RESEARCH ARTICLE A Snapshot of the Hepatic Transcriptome ~ A Snapshot of the Hepatic Transcriptome: Ad Libitum Alcohol Intake Suppresses Expression of Cholesterol Synthesis Genes in Alcohol-Preferring (P) Rats Jonathon D. Klein1,2, Jeremy B. Sherrill2, Gabriella M. Morello2, Phillip J. San Miguel3,4, Zhenming Ding5, Suthat Liangpunsakul6, Tiebing Liang6,
(PDF) A Snapshot of the Hepatic Transcriptome: Ad Libitum ~ A Snapshot of the Hepatic Transcriptome: Ad Libitum Alcohol Intake Suppresses Expression of Cholesterol Synthesis Genes in Alcohol-Preferring (P) Rats.
A snapshot of the hepatic transcriptome: ad libitum ~ To address this gap, we captured the global, steady-state liver transcriptome following a 23 week free-choice, moderate alcohol consumption regimen (∼ 7.43 g ethanol/kg/day) in inbred alcohol-preferring (iP10a) rats.
Metabolites / Free Full-Text / Characterization of ~ Metabolomic approaches provide an overview of the profiles of metabolites such as amino acids, sugars, and lipids in biofluids and tissues [1,2,3].Metabolites act as essential energy sources for cells, organs, and tissues, as well as key players for multiple biological processes.
The hepatic transcriptome in human liver disease ~ Questions about hepatic transcriptome differences due to factors such as diet, age, gender and ethnicity remain unanswered. Additionally, the relationship of the hepatic transcriptome to the proteome has demonstrated that a significant proportion of proteins are not regulated by the expression of mRNA transcripts.
Analysis of hepatic gene expression during fatty liver ~ To read the full-text of this research, you can request a copy directly from the authors.
Alcoholic liver disease / Postgraduate Medical Journal ~ The safe limits for alcohol intake are controversial. Guidelines recommended by the Royal College of Physicians advise a weekly limit of 21 units (210 g) of alcohol in men and 14 units in women. . associations between ALD risk and polymorphisms of the genes encoding the cytochromeP-450 CYP2E115 and TNF- . (1994) Malotilate, a .
REFERENCES - UpToDate ~ Patients with alcoholic hepatitis typically have a history of daily heavy alcohol use (>100 g per day) for more than 20 years and in some cases, patients will have recently increased their alcohol intake in response to stressful life events .
Alcoholic Liver Disease: Introduction ~ Initial hypotheses suggested that alcoholic liver disease was a result of alcohol intake in the face of poor nutrition. Today, however, it is understood that while malnutrition may worsen the severity of disease and obesity may increase the risk of developing disease, alcoholic liver disease does indeed occur in well-nourished
RESEARCH Open Access Analysis of hepatic transcriptome ~ The hepatic gene expression of each group was then measured using high-throughput analysis methods (RNA-Seq). . cholesterol, lipid storage, phosphatidylinositol, steroid, phospholipid and triglyceride (p<0.05) (Additional . genes in hepatic transcriptome. 268 genes were up-regulated from control to SNE, 60 genes were up-regulated from SNE .
Hepatic transcriptomic signatures of statin treatment are ~ The expression of 8 statin-regulated genes identified from our study were mapped to the hepatic LXR/RXR signaling pathway, including genes from cholesterol biosynthesis (e.g. HMGCR, CYP51A1), cholesterol transport (ABCG1) and lipogenesis (ACACA, FASN, SCD).
Alcoholic hepatitis - Symptoms and causes - Mayo Clinic ~ Untreated, it can lead to cirrhosis. If you have hepatitis C and drink alcohol, you're far more likely to develop cirrhosis than if you didn't drink. Check before mixing medications and alcohol. Ask your doctor if it's safe to drink alcohol when taking your prescription medications. Read the warning labels on over-the-counter medications.
The Response of Hepatic Transcriptome to Dietary ~ When the hepatic transcriptome of both strains was compared on the same diet using the same criteria (twofold change, P<0.05), several genes were found to be expressed differently (Fig. 1B). Five genes were downregulated and four genes upregulated in the PHHC rats. The vast majority of those genes, except for Apof,
Alcoholic Hepatitis / NEJM ~ The association between alcohol intake and alcoholic liver disease has been well documented, although cirrhosis of the liver develops in only a small proportion of heavy drinkers. This review focus.
UpToDate ~ The amount of alcohol intake that puts an individual at risk for alcoholic hepatitis is not known, but the majority of patients have a history of heavy alcohol use (more than 100 g per day) for two or more decades . This topic will review the prognosis and management of patients with alcoholic hepatitis.
Acute alcoholic hepatitis - WikEM ~ ↑Basra, Gurjot,et. al. "Symptoms and Signs of Acute Alcoholic Hepatitis." World J Hepatol. 2011 May 27; 3(5): 118–120. ↑ Ostapowicz G, Fontana RJ, Schiodt FV, et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med. 2002 Dec 17; 137(12): 947-54.
Alcoholic Hepatitis - an overview / ScienceDirect Topics ~ To mimic alcohol drinking patterns in AH patients, researchers recently developed a chronic-plus-binge ethanol feeding model that induces higher levels of steatosis, serum ALT, and liver inflammation than ad libitum chronic ethanol feeding. 48,94,104 Hepatic neutrophil infiltration, which is a hallmark of AH, is markedly elevated after chronic .
Analysis of Transcriptome and Metabolome Profiles ~ After 16 weeks, the HFD rats developed significantly higher body and liver weight in comparison with SC rats, although they consumed the same amount of food. The total cholesterol and triglyceride liver contents were increased by 25.7-fold (2.1 vs 54.1 mg/g liver, P < .01) and 8.5-fold (12.4 vs 105.5 mg/g liver, P < .01), respectively .
Alcoholic hepatitis - Cancer Therapy Advisor ~ Alcoholic hepatitis is an acute reaction to prolonged excessive alcohol consumption. Mild forms of the syndrome improve without intervention, but when severe there is nearly a 50% 1 month .
Hepatitis and Alcohol – Is it safe for me to have a drink ~ So ideally, it may be best not to have any alcohol at all. For some people however, it may be possible to limit your intake of alcohol so as to reduce the possibility of further damage to your liver. If you have hepatitis, it is recommended that you drink no more than ONE standard drink per day, and have at least four alcohol-free days per week.
Hepatitis C and Alcohol Consumption - Hepatitis C - MedHelp ~ On univariate analysis, heavy alcohol use (>50 g/day) was associated with an increase in mean fibrosis (P =.01). Such an association could not be demonstrated for light and moderate alcohol use. For each category of alcohol intake (none, light, moderate, and heavy), a spectrum of fibrosis was observed.
Alcoholic Hepatitis - Medscape ~ Background. Alcoholic hepatitis is a syndrome of progressive inflammatory liver injury associated with long-term heavy intake of ethanol. [1] The pathogenesis is not completely understood. [2] The relative risk of cirrhosis rises significantly for alcohol intake above 60 g/day for men and 20 g/day for women over a decade.