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Nitric Oxide Synthase and Breast Cancer Role of TIMP1 in NOmediated Akt Activation
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Nitric Oxide Synthase and Breast Cancer: Role of TIMP-1 in ~ Prediction of therapeutic response and cancer patient survival can be improved by the identification of molecular markers including tumor Akt status. A direct correlation between NOS2 expression and elevated Akt phosphorylation status has been observed in breast tumors. Tissue inhibitor matrix metalloproteinase-1 (TIMP-1) has been proposed to exert oncogenic properties through CD63 cell .
Nitric Oxide Synthase and Breast Cancer: Role of TIMP-1 in ~ Nitric Oxide Synthase and Breast Cancer: Role of TIMP-1 in NO-mediated Akt Activation Lisa A. Ridnour 1 *, Kimberly M. Barasch 1 , Alisha N. Windhausen 1 , Tiffany H. Dorsey 2 , Michael M. Lizardo 3 ,
(PDF) Nitric Oxide Synthase and Breast Cancer: Role of ~ Citation: Ridnour LA, Barasch KM, Windhausen AN, Dorsey TH, Lizardo MM, et al. (2012) Nitric Oxide Synthase and Breast Cancer: Role of TIMP-1 in NO-mediated Akt Activation. PLoS ONE 7(9): e44081 .
(PDF) Nitric Oxide Synthase and Breast Cancer: Role of ~ Nitric Oxide Synthase and Breast Cancer: Role of TIMP-1in NO-mediated Akt Activation
Nitric Oxide Synthase and Breast Cancer: Role of TIMP-1 in ~ Nitric oxide 19 : 65 - 67 . 21. Ridnour LA , Thomas DD , Switzer C , Flores-Santana W , Isenberg JS , et al. ( 2008 ) Molecular mechanisms for discrete nitric oxide levels in cancer . Nitric oxide 19 : 73 - 76 . 22. Loibl S , Buck A , Strank C , von Minckwitz G , Roller M , et al. ( 2005 ) The role of early expression of inducible nitric oxide .
Nitric oxide synthase activity in human breast cancer ~ Nitric oxide (NO) is generated by a family of isoenzymes (NO synthases) expressed in a wide range of mammalian cells. We have recently reported NO synthase expression in human gynaecological cancers.
Nitric Oxide and Cancer: Pathogenesis and Therapy ~ Research over the last years has convincingly demonstrated an important role for arginase and nitric oxide (NO) synthase (NOS) in tumor immunobiology [1, 2]. Earlier reports focused on the .
Nitric Oxide Induces TIMP-1 Expression by Activating the ~ Nitric Oxide Increases the Cytokine-induced Amount of Extracellular TIMP-1—Recently, we have demonstrated that NO potently inhibits the IL-1β-induced expression of MMP-9, which results in a reduction of the gelatinolytic contents within conditioned media of cytokine-treated MC .
Advances in Breast Cancer Therapy Using Nitric Oxide and ~ Loibl S, Buck A, Strank C, von Minckwitz G, Roller M, Sinn HP, Schini-Kerth V, Solbach C, Strebhardt K, Kaufmann M. The role of early expression of inducible nitric oxide synthase in human breast cancer. Eur J Cancer. 2005;41:265–71. PubMed CrossRef Google Scholar
Nitric Oxide Synthase Variants and Disease-Free Survival ~ Purpose: Numerous chemotherapeutic agents are cytotoxic through generation of reactive species, and variability in genes related to oxidative stress may influence disease-free survival (DFS). We examined relationships between DFS and variants in NOS3 , as well as NQO1, NQO2 , and CBR3 , among treated and untreated breast cancer patients in a Southwest Oncology Group clinical trial (S8897).
Nitric Oxide and Nitric Oxide Donors in Preclinical ~ S. Pervin, R. Singh, G. ChaudhuriNitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): potential role of cyclin D1 Proc Natl Acad Sci U S A, 98 (6) (2001), pp. 3583-3588
Influence of Nitric Oxide Synthase II - Cancer Research ~ The relationship between nitric oxide (NO) synthase II (NOS II) expression and the metastatic ability of tumor cells is inconclusive. We determined the role of host NOS II expression in the growth and metastasis of the B16-BL6 murine melanoma and M5076 murine ovarian sarcoma cell lines. The cells were either s.c. or i.v. injected into syngeneic wild-type (NOS II+/+) and NOS II-null (NOS II .
The Role of Nitric Oxide Synthase Uncoupling in Tumor ~ The Role of Nitric Oxide Synthase Uncoupling in Tumor Progression Christopher S. Rabender1, Asim Alam1, Gobalakrishnan Sundaresan2, Robert J. Cardnell3, Vasily A.Yakovlev1, Nitai D. Mukhopadhyay4, Paul Graves5, Jamal Zweit2, and Ross B. Mikkelsen1 Abstract Here, evidence suggests that nitric oxide synthases (NOS) of
Nitric oxide in cancer metastasis - PubMed Central (PMC) ~ In the last two decades, the function of NO • in the regulation of cancer formation, progression and metastasis has been extensively investigated.[5, 6] Activation of nitric oxide synthase (NOS) and elevation of NO • have exhibited an antitumor nature,[7–9] however, NO • may also promote cancer formation and progression.[10–12 .
Role of Endothelial Nitric Oxide Synthase in Breast Cancer ~ Breast cancer (BC) is the most common form of carcinoma and a primary cause of morbidity and mortality globally. Oxidative stress represents as an important factor in carcinogenesis and may play a role in initiation and progression of tumors. Oxidative stress–induced NO• damage to DNA includes a multitude of lesions, many of which are mutagenic and have multiple roles in cancer and aging.
Inducible Nitric Oxide Synthase Drives - Cancer Research ~ Melanoma is one of the cancers of fastest-rising incidence in the world. Inducible nitric oxide synthase (iNOS) is overexpressed in melanoma and other cancers, and previous data suggest that iNOS and nitric oxide (NO) drive survival and proliferation of human melanoma cells. However, specific mechanisms through which this occurs are poorly defined. One candidate is the PI3K–AKT–mTOR .
Endothelium and Nitric Oxide: Interactions in Cancer ~ The importance of GTPase Rac1 expression in tumors was first demonstrated in breast cancer . NO derived from eNOS activation plays an important role in recruitment and induction of migration of tumor cells precursors, . A role for nitric oxide and for nitric oxide synthases in tumor biology. For Immunopathol Dis Therap, 3 (2012), pp. 169 .
Expression of nitric oxide synthase in gastric cancer ~ 4. Discussion. An increased expression of NOS has been observed not only in endothelial cells in ulcerative colitis , but also in human carcinoma cell lines and human gynecological, breast, gastric, and central nervous system tumors. Nitric oxide, a labile compound synthesized by NOS, is a major regulator not only of physiological vascular tone but also of the abnormal vascularity associated .
Inhibition of induced nitric oxide synthase enhances the ~ Toll-like receptor (TLR) agonists have been shown to have anti-tumor activity in basic research and clinical studies. However, TLR agonist monotherapy in cancer treatment dose not sufficiently eliminate tumors. Activation of the innate immune response by TLR agonists and other pathogen-associated molecular patterns is effective for driving adaptive immunity via interleukin (IL)-12 or IL-1, but .
Role of nitric oxide synthase in the development of bone ~ Spinal nitric oxide is involved in the mechanisms of pain generation and transmission during inflammatory and neuropathic pain. The aim of the present study was to explore the role of spinal nitric oxide in the development of bone cancer pain. 2×10 5 osteosarcoma cells were implanted into the intramedullary space of right femurs of C3H/HeJ mice to induce a model of ongoing bone cancer.
Frontiers / Nitric Oxide Synthase: Non-Canonical ~ Science can move ahead by questioning established or canonical views and, so it may be with the enzymes, nitric oxide synthases (NOS). Nitric oxide (NO) is generated by NOS isoforms that are often described by their tissue-specific expression patterns. NOS1 (nNOS) is abundant in neural tissue, NOS2 is upregulated in activated macrophages and known as inducible NOS (iNOS), and NOS3 (eNOS) is .
Candidate pathways linking inducible nitric oxide synthase ~ Other studies discovered that NOS2 expression correlates with increased Akt phosphorylation in breast tumors, and that NO induces Akt phosphorylation and activation of the oncogenic Akt pathway in breast cancer cells in culture. 13, 14 Akt activation is a pro-survival signal that suppresses the activation of key factors like BAD and caspase-9 .
Cancer Immunotherapy: Chapter 34. Arginase, Nitric Oxide ~ Buy Cancer Immunotherapy: Chapter 34. Arginase, Nitric Oxide Synthase, and Novel Inhibitors of L-arginine Metabolism in Immune Modulation: Read Kindle Store Reviews -
The Role of Nitric Oxide Synthase Uncoupling in Tumor ~ Here, evidence suggests that nitric oxide synthases (NOS) of tumor cells, in contrast with normal tissues, synthesize predominantly superoxide and peroxynitrite. Based on high-performance liquid chromatography analysis, the underlying mechanism for this uncoupling is a reduced tetrahydrobiopterin:dihydrobiopterin ratio (BH4:BH2) found in breast, colorectal, epidermoid, and head and neck tumors .
Nitric oxide synthase - Wikipedia ~ Nitric oxide synthases (EC 1.14.13.39) (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine.NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter.