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Gene Silencing and Activation of Human Papillomavirus 18 Is Modulated by Sense Promoter Associated RNA in Bidirectionally Transcribed Long Control Region
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Gene Silencing and Activation of Human Papillomavirus 18 ~ Gene Silencing and Activation of Human Papillomavirus 18 Is Modulated by Sense Promoter Associated RNA in Bidirectionally Transcribed Long Control Region Muzaffer Ahmad Kassab , 1 Madeeha Mudassir , 1 Anand Singh , 2 Muthuraman N , 3 Mohita Bhagat , 1 Jayanth Kumar Palanichamy , 1 Pradeep Ramalingam , 4 Kunzang Chosdol , 1 Subrata Sinha , 5 and .
(PDF) Gene Silencing and Activation of Human ~ Gene Silencing and Activation of Human Papillomavirus 18 Is Modulated by Sense Promoter Associated RNA in Bidirectionally Transcribed Long Control Region.pdf Available via license: CC BY 4.0 .
Gene Silencing and Activation of Human Papillomavirus 18 ~ Gene Silencing and Activation of Human Papillomavirus 18 Is Modulated by Sense Promoter Associated RNA in Bidirectionally Transcribed Long Control Region. By Muzaffer Ahmad Kassab, Madeeha Mudassir, Anand Singh, Muthuraman N, Mohita Bhagat, Jayanth Kumar Palanichamy, Pradeep Ramalingam, Kunzang Chosdol, Subrata Sinha and Parthaprasad Chattopadhyay
Gene Silencing and Activation of Human Papillomavirus 18 ~ Gene Silencing and Activation of Human Papillomavirus 18 Is Modulated by Sense Promoter Associated RNA in Bidirectionally Transcribed Long Control Region By Muzaffer Ahmad Kassab, Madeeha Mudassir, Anand Singh, Muthuraman N, Mohita Bhagat, Jayanth Kumar Palanichamy, Pradeep Ramalingam, Kunzang Chosdol, Subrata Sinha and Parthaprasad Chattopadhyay
RNA Interference of Human Papillomavirus Type 18 E6 and E7 ~ Gene Silencing and Activation of Human Papillomavirus 18 Is Modulated by Sense Promoter Associated RNA in Bidirectionally Transcribed Long Control Region Article Full-text available
Human Papillomavirus 18 Genetic Variation and Cervical ~ INTRODUCTION. High-risk human papillomavirus (HPV) types are the etiological agents of cervical cancer. HPV18 was first described in 1984 and is the prototype member of the alpha-7 HPV species.Based upon its enrichment in cervical cancer compared to the level in cytologically normal women and its presence in 16% of cervical cancers worldwide (), HPV18 is widely accepted as the second most .
Silencing of Integrated Human Papillomavirus-16 Oncogenes ~ Double-stranded RNAs or small interfering RNAs (siRNA) targeting the promoters of genes are known to cause gene knockdown by a process known as transcriptional gene silencing (TGS). We screened multiple siRNAs homologous to one of the NF-1 binding sites in the human papillomavirus-16 (HPV-16) enhancer and identified one siRNA which causes specific TGS of the HPV-16 oncogenes E6 and E7 when .
Dr. Parthaprasad Chattopadhyay - AIIMS ~ Kassab MA, Mudassir M, Singh A, N M, Bhagat M, Palanichamy JK, Ramalingam P, Chosdol K, Sinha S, Chattopadhyay P. (2015) Gene Silencing and Activation of Human Papillomavirus 18 Is Modulated by Sense Promoter Associated RNA in Bidirectionally Transcribed Long Control Region. PLoS One. 10: e0128416
WHO / Human Papillomavirus ~ Human papillomavirus (HPV) is a small, non-enveloped deoxyribonucleic acid (DNA) virus that infects skin or mucosal cells. The circular, double-stranded viral genome is approximately 8-kb in length. The genome encodes for 6 early proteins responsible for virus replication and 2 late proteins, L1 and L2, which are the viral structural proteins.
Dr. Subrata Sinha - AIIMS NEW ~ 13. Kassab MA, Mudassir M, Singh A, N M, Bhagat M, Palanichamy JK, Ramalingam P, Chosdol K, Sinha S, Chattopadhyay P. Gene Silencing and Activation of Human Papillomavirus 18 Is Modulated by Sense Promoter Associated RNA in Bidirectionally Transcribed Long Control Region.PLoS One. 2015 Jun 5;10(6) 14.
Human papillomavirus molecular biology - ScienceDirect ~ 1. Introduction. With a prevalence of 70 million cases and an incidence of 14 million new transmissions each year, human papillomavirus (HPV) infections of the anogenital tract are the most common sexually transmitted diseases in the US .High-risk (HR) HPVs are the causative agents of cervical cancer and, worldwide, it is estimated that 500,000 cases of cervical cancer occur each year, which .
Transcriptional gene silencing in humans / Nucleic Acids ~ Transcriptional gene silencing in humans. The study of small non-coding RNA-directed TGS has been carried out in various model organisms such as plants (Arabidopsis thaliana), yeast (Saccharomyces pombe), flies (Drosophila melanogaster) and worms (C. elegans) (reviewed extensively in (7, 8)).A decade ago, the first report of RNA-directed TGS in human cells was observed when exogenous siRNAs .
Gene Activation and Gene Silencing / Plant Physiology ~ B, Models for RNA-mediated silencing. The common theme is that silencing is triggered by a double-stranded RNA molecule (dsRNA). If the RNA is homologous to the promoter, TGS can occur. If the RNA is homologous to the transcribed mRNA (symbolized by open reading frame), transcription is not affected, but the RNA is degraded.
Development of human papillomavirus - Gene Therapy ~ Both the pFS105 and pFS106 plasmids contain the E1 gene under the control of the SV40 early promoter, the E2 gene driven by the HSVtk promoter, and the HPV-18 ori (nt 7714–119). The difference .
Identification of human papillomavirus (HPV) 16 DNA ~ Introduction. Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, accounting for 3–5% of all cancers. 1 Recently, the incidence of oropharyngeal cancer (OPC) has been reported to be increasing markedly. This is mainly because the number of human papillomavirus (HPV)‐related oropharyngeal cancers (HPV‐OPC) has risen globally, 2 while the incidence of .
The Biology and Life-Cycle of Human Papillomaviruses ~ Cancer progression is facilitated when integration preserves the integrity of the long control region (LCR) and the E6 and E7 genes and the 5′ portion of the E1 gene, but disrupts the ability of the integrated genome to express the DNA-binding protein that represses the viral early promoter, and the full-length E1 gene, which can regulate .
Human Papillomavirus (HPV): Practice Essentials ~ Human papillomavirus (HPV) produces epithelial tumors of the skin and mucous membranes. The current classification system for HPV, which is based on similarities in genomic sequences, generally correlates with the 3 clinical categories applied to HPV infection: Anogenital or mucosal (further subclassified as latent [asymptomatic], subclinica.
Epidemiologic Classification of Human Papillomavirus Types ~ Original Article from The New England Journal of Medicine — Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer . control women, types 16, 18, 45, 31, 6 .
Human Papillomavirus: Gene Expression and Regulation ~ Figure 2. Early gene expression profile of human papillomavirus type 16 in W12 cervical epithelial cells. Open boxes represent open reading frames, with the proteins encoded indicated by bold text.
Molecular Diagnostics of Human Papillomavirus / Laboratory ~ Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States, affecting men and women. 1 It is estimated that more than 24 million men and women in the United States are currently infected with HPV. 2, 3 More than 4 million new HPV infections are reported in the United States annually, and about 1%–10% of the sexually active U.S. population is infected at .
Genetic characterization of the human papillomavirus (HPV ~ HPV 18 is associated with 2 divergent phenotypes: (i) aggressive cervical cancer and a preponderance of cancer relative to cervical intra‐epithelial neoplasia (CIN) and (ii) benign warty lesions of the cervix. The E2 gene of HPV 18 encodes a regulatory protein that represses viral oncogene transcription and is involved in viral replication. Variation within the E2 gene of HPV 18 and its .
Papillomavirus Research - Journal - Elsevier ~ Papillomavirus Research aims to publish top quality articles, describing innovative research advances in the field of human tumour virology, including Epstein Barr virus (EBV), Human T cell leukemia virus (HTLV), Polyoma virus (PyV), Merkel Cell PolyomaVirus (MCPyV), Kaposi's Sarcoma Herpes Virus (KSHV) and Papillomaviruses (PV), as well as other related animal tumour virus models.
The Cell Cycle Timing of Human Papillomavirus DNA Replication ~ Viruses manipulate the cell cycle of the host cell to optimize conditions for more efficient viral genome replication. One strategy utilized by DNA viruses is to replicate their genomes non-concurrently with the host genome; in this case, the viral genome is amplified outside S phase. This phenomenon has also been described for human papillomavirus (HPV) vegetative genome replication, which .
Human papillomavirus type 16 E6 induces cervical cancer ~ MicroRNA (miRNA or miR) is a class of small non-coding endogenous RNA of 19–24 nucleotides in length. More than 50% of miRNA genes are located in cancer-associated genomic regions or in fragile .
Human Papillomavirus: Gene Expression and Regulation ~ RNA Stability Human papillomavirus gene regulation is also controlled at other post-transcriptional levels. In particular, expression of the virus capsid proteins L1 and L2 is regulated largely .