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Examining the effects of uric acidlowering on markers vascular of calcification and CKDMBD A posthoc analysis of a randomized clinical trial
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(PDF) Examining the effects of uric acid-lowering on ~ Examining the effects of uric acid-lowering on markers vascular of calcification and CKD-MBD; A post-hoc analysis of a randomized clinical trial October 2018 PLoS ONE 13(10):e0205831
Effects of uric acid on vascular endothelial function from ~ This study was designed to investigate the effects of uric acid on vascular endothelial function in measurements carried out either at the bedside or the laboratory bench. First, we performed .
Uric Acid Is Associated With Inflammatory Biomarkers and ~ Introduction. Uric acid (UA), the final product of purine degradation, has been associated with obesity, metabolic syndrome, dysglycemic conditions, diabetes mellitus, hypertension, endothelial dysfunction, cardiovascular disease, and chronic kidney disease, most likely as a consequence of westernized lifestyle and environment. 1 â 13 However, the causal mechanisms linking elevated UA levels .
The significance of uric acid in the diagnosis and ~ 1 Introduction. Parkinson disease (PD), which can affect over 1% of the population above 65 years of age, is a neurodegenerative disease characterized by chronic and progressive loss of dopaminergic neurons in substansia nigra pars compacta. PD symptoms include rigidity, postural instability, tremor at rest, and slowness or absence of voluntary movement, and even neuropsychiatric symptoms.
URIC ACID AND ECZEMA / JAMA / JAMA Network ~ Somehow uric acid has managed to retain a prominence in the field of clinical medicine that seems to be out of proportion to its scientific merits from the standpoint of the actual evidence afforded by pathologic chemistry. The physiologic significance of this purine derivative is unquestioned. The.
The Relationship Between Uric Acid and Inflammatory Markers ~ A double blind placebo controlled randomized trial of the effect of acute uric acid changes on inflammatory markers in humans: A pilot study. PLoS One. 2017 Aug 7;12(8):e0181100. doi: 10.1371/journal.pone.0181100. eCollection 2017.
Uric acid and cardiovascular risk considered: an update ~ Similar results were described in subsequent analysis of the LIFE trial, where the higher decline in serum uric acid levels reached with a losartan based regimen when compared with the atenolol based one, explained 29% of the treatment effect on the primary composite end point of fatal and non-fatal myocardial infarction and stroke (21).
Statin Use and Leg Functioning in Patients With and ~ Randomized trial of the effects of cholesterol-lowering with simvastatin on peripheral vascular and other major vascular outcomes in 20,536 people with peripheral arterial disease and other high .
AHA Statistical Update - PDF Free Download ~ son and Tom Schneider for their editorial contributions, and Karen Modesitt for her administrative assistance. Summary E.
Uric Acid Predicts Clinical Outcomes in Heart Failure ~ Uric acid stimulates vascular smooth muscle cell proliferation by increasing platelet-derived growth factor A-chain expression. J Biol Chem. 1991; 266: 8604â8608. Medline Google Scholar; 18 Kang D-H, Nakagawa T, Feng L, et al. A role for uric acid in the progression of renal disease. J Am Soc Nephrol. 2002; 13: 2888â2897.
Rheumatoid Arthritis - ScienceDirect ~ The impact of novel biologic therapies on blood pressure remains controversial as data from the Behandel-Strategieen (BEST) trial suggests that tumor necrosis factor-α inhibitors (TNFα) can reduce blood pressure , while a recent meta-analysis of a total of 6321 subjects with RA from 11 randomized clinical trials demonstrated that .
Uric acid and cardiovascular disease - ScienceDirect ~ Uric acid (UA) is an end product of purine metabolism in humans and great apes. . Experimental and clinical studies have evidenced several mechanisms through which elevated UA level exerts deleterious effects on cardiovascular health including increased oxidative stress, reduced availability of nitric oxide and endothelial dysfunction .
Serum uric acid levels and inflammatory markers with ~ Correlation of serum uric acid levels with inflammatory markers (CRP, PLR, NLR) was evaluated as was the logistic regression analysis for determinants of nondipper pattern. RESULTS: Nondipper pattern was noted in 65.2% and 79.7% of non-CKD and CKD patients, respectively.
Serum Uric Acid Levels in Patients with Alzheimer's ~ Methods. We conducted a meta-analysis to compare serum UA levels between AD patients and healthy controls by the random-effects model. Studies were identified by searching PubMed, ISI Web of Science, EMBASE, and the Cochrane library databases from 1966 through July 2013 using the Medical Subject Headings and keywords without restriction in languages.
Risks of High Uric Acid: How to Reduce It - Life Extension ~ These findings in diabetic rats led a group of Indian researchers to perform a randomized, controlled clinical trial to determine the efficacy and tolerability of a standardized extract of T. bellerica at lowering uric acid levels in humans. 11. For the study, 110 people with elevated uric acid received one of the following: a placebo, 40 mg daily of the uric-acid lowering drug febuxostat, 500 .
Sugar, Uric Acid, and the Etiology of Diabetes and Obesity ~ The intake of added sugars, such as from table sugar (sucrose) and high-fructose corn syrup has increased dramatically in the last hundred years and correlates closely with the rise in obesity, metabolic syndrome, and diabetes. Fructose is a major component of added sugars and is distinct from other sugars in its ability to cause intracellular ATP depletion, nucleotide turnover, and the .
Uric Acid as a Marker of Kidney Disease: Review of the ~ Uric acid has been implicated in the pathophysiology of renal disease; however renal clearance makes a causal relationship difficult to prove. We examine the current literature to support a potential role of uric acid in the development of kidney disease and to determine the potential to use uric acid as a marker for future renal decline. After review, we conclude that uric acid is .
What Is the Biological Function of Uric Acid? An ~ The main aim of the present study was to investigate the biological function of uric acid. The level of uric acid in different organs in normal male rats was determined with uric acid assay kits, and the expression level of genes in the organs was determined by RNA quantitative sequencing. The correlation analysis between uric acid in the organs and gene expression (measured by FPKM value) was .
Uric acid and inflammatory markers / European Heart ~ Major chronic diseases were ascertained according to pre-established criteria that combined information from physician diagnosis, medical records, clinical examination, and blood tests. 33 In the analysis presented here, CVD is defined as the occurrence of angina, or/and myocardial infarction, or/and congestive heart failure, whereas .
Uric Acid & Cardiovascular Disease - ECR Journal ~ Bose B, Badve SV, Hiremath SS, et al. Effects of uric acidlowering therapy on renal outcomes: a systematic review and meta-analysis. Nephrol Dial Transplant 2014;29:406â13. Crossref / PubMed; Fang J, Alderman MH. Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971â1992.
Silent Dangers of High Uric Acid - - Life Extension ~ Fortunately, scientists have found a plant extract that safely delivers uric acid-reducing effects. 8. In this article, you will learn about a tannin-rich fruit that was shown in a controlled human trial to safely reduce uric acid to healthy target levels in 88.8% of study subjects. 8 . How Excess Uric Acid Occurs
Interactive effect of serum uric acid and total bilirubin ~ Serum uric acid (SUA) at high levels and bilirubin at low levels were potent antioxidant but it was uncertain that whether SUA and total bilirubin (TBIL) had additive interaction for the risk of .
RURCU - Clinical: Uric Acid, Random, Urine ~ RURCU : Uric acid is the end-product of purine metabolism. It is freely filtered by the glomeruli and most is reabsorbed by the tubules. There is also active tubular secretion. Increased levels of uric acid in the urine usually accompany increased plasma uric acid levels unless there is a decreased excretion of uric acid by the kidneys.
RETRACTED ARTICLE: Effects of uric acid on endothelial ~ An increase in serum uric acid (UA) occurs during the early and middle stages of chronic kidney disease (CKD) and aggravates the deterioration of kidney function. This study aims to explore the relation between UA and endothelial dysfunction in early CKD and its mechanisms in a murine model. The experimental animals were randomly divided into three groups (n = 10): sham-operation group .
The Role of Uric Acid in the Pathogenesis of Hypertension ~ The effects of uric acid on the blood vessel are shown. The first phase is direct, uric acidâdependent activation of the reninâangiotensin system and downâregulation of the nitric oxide (NO) production, leading to vasoconstriction. At this stage, uric acid reduction results in vascular relaxation and improved blood pressure.