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A Recombinant Vesicular Stomatitis VirusBased Lassa Fever Vaccine Protects Guinea Pigs and Macaques against Challenge with Geographically and Genetically Distinct Lassa Viruses

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A Recombinant Vesicular Stomatitis Virus-Based Lassa Fever ~ Citation: Safronetz D, Mire C, Rosenke K, Feldmann F, Haddock E, Geisbert T, et al. (2015) A Recombinant Vesicular Stomatitis Virus-Based Lassa Fever Vaccine Protects Guinea Pigs and Macaques against Challenge with Geographically and Genetically Distinct Lassa Viruses. PLoS Negl Trop Dis 9(4): e0003736.

(PDF) A Recombinant Vesicular Stomatitis Virus-Based Lassa ~ A Recombinant Vesicular Stomatitis Virus-Based Lassa Fever Vaccine Protects Guinea Pigs and Macaques against Challenge with Geographically and Genetically Distinct Lassa Viruses

A Recombinant Vesicular Stomatitis Virus-Based Lassa Fever ~ A Recombinant Vesicular Stomatitis Virus-Based Lassa Fever Vaccine Protects Guinea Pigs and Macaques against Challenge with Geographically and Genetically Distinct Lassa Viruses By David Safronetz, Chad Mire, Kyle Rosenke, Friederike Feldmann, Elaine Haddock, Thomas Geisbert and Heinz Feldmann

Full article: Recombinant vesicular stomatitis virus ~ Matassov D, Marzi A, Latham T, Xu R, Ota-Setlik A, Feldmann F, Geisbert JB, Mire CE, Hamm S, Nowak B, et al. Vaccination with a highly attenuated recombinant vesicular stomatitis virus vector protects against challenge with a lethal dose of Ebola virus. J Infect Dis. 2015;212: 443 – 51. doi: 10.1093/infdis/jiv316.

Recombinant vesicular stomatitis virus vector vaccines for ~ detailed characterization of vaccine platforms is needed. The vesicular stomatitis virus (VSV) has been established as a robust vaccine vector backbone for infectious diseases for well over a decade. The recent clinical trials testing the vaccine candidate VSV-EBOV against EBOV disease now have added a substantial

Viruses / Free Full-Text / Vesicular Stomatitis Virus ~ A Recombinant Vesicular Stomatitis Virus-Based Lassa Fever Vaccine Protects Guinea Pigs and Macaques Against Challenge with Geographically and Genetically Distinct Lassa Viruses. PLoS Negl. Trop. Dis. 2015 , 9 , e0003736.

Vesicular Stomatitis Virus–Based Vaccines against Lassa ~ We demonstrated that previous vaccination with a vesicular stomatitis virus (VSV)–based Lassa virus vaccine does not alter protective efficacy of subsequent vaccination with a VSV-based Ebola virus vaccine. These findings demonstrate the utility of VSV-based vaccines against divergent viral pathogens, even when preexisting immunity to the vaccine vector is present.

Vesicular Stomatitis Virus-Based Vaccines against Lassa ~ The larger monkey cartoon is part of a figure from "Vesicular Stomatitis Virus-Based Vaccines against Lassa and Ebola Viruses" by (Marzi et al., 2015); licensed under CC BY 4.0; the focus on the .

A Recombinant Vesicular Stomatitis Virus Ebola Vaccine / NEJM ~ Geisbert TW, Daddario-Dicaprio KM, Geisbert JB, et al. Vesicular stomatitis virus-based vaccines protect nonhuman primates against aerosol challenge with Ebola and Marburg viruses. Vaccine 2008 .

Lassa-Vesicular Stomatitis Chimeric Virus Safely Destroys ~ Viruses and cells. The VSV-wtG (where wt is “wild type”) included the Indiana serotype for the G protein. Chimeric VSVs expressing the glycoprotein from the Josiah strain of Lassa fever virus (VSV-LASV-GPC), the SAD B19 strain of rabies virus (VSV-RABV-G), the Armstrong 53b strain of lymphocytic choriomeningitis virus (VSV-LCMV-GPC), the Mayinga/Zaire strain of Ebola virus (VSV-EBOV-GP .

Single-Vector, Single-Injection Recombinant Vesicular ~ Safronetz D, Mire C, Rosenke K, Feldmann F, Haddock E, Geisbert T, Feldmann H (2015) A recombinant vesicular stomatitis virus-based Lassa fever vaccine protects guinea pigs and macaques against challenge with geographically and genetically distinct Lassa viruses. PLoS Negl Trop Dis 9, e0003736 CrossRef PubMed PubMedCentral Google Scholar

Vesicular Stomatitis : USDA ARS ~ Introduction.Vesicular stomatitis virus (VSV) is a rhabdovirus which causes re-emerging disease in cattle, horses and swine. For the past two decades, VSV has caused disease outbreaks in the western US every 2-9 years ('82-83, '85-86, '95, '97-98, '04-'06).

A Vesicular Stomatitis Virus-Based Hepatitis B Virus ~ It is estimated that >2 billion people worldwide have been infected with hepatitis B virus (HBV), placing it among the world's most common infectious diseases ().HBV is a serious public health concern as regions of high endemicity, including Southeast Asia, and sub-Saharan Africa, consistently report a chronic carrier prevalence of 8 to 15% (). .

Recombinant Vesicular Stomatitis Virus Expressing ~ The genes encoding the respiratory syncytial virus (RSV) attachment (G) and fusion (F) envelope glycoproteins were expressed separately as additional genes in recombinant vesicular stomatitis viruses (VSV). Cells infected with the VSV-RSV F recombinant formed large syncytia illustrating the fusion activity of F in absence of other RSV proteins.

Vesicular stomatitis virus-based vaccines protect nonhuman ~ Considerable progress has been made over the last decade in developing candidate preventive vaccines that can protect nonhuman primates against Ebola and Marburg viruses. A vaccine based on recombinant vesicular stomatitis virus (VSV) seems to be particularly robust as it can also confer protection when administered as a postexposure treatment.

Vesicular Stomatitis Virus - an overview / ScienceDirect ~ S.P.J. Whelan, in Encyclopedia of Virology (Third Edition), 2008. Vesicular stomatitis virus (VSV) has been extensively studied as a prototype of the nonsegmented negative-strand RNA viruses. The relative safety of the virus combined with its abundant replication in a broad range of cultured cells have favored the use of VSV in research laboratories.

Vesicular Importance Stomatitis ~ Vesicular stomatitis mainly affects equids, cattle and swine. Sheep and goats can develop clinical signs, although this is uncommon, and South American camelids have also been affected. Antibodies to vesicular stomatitis viruses (VSV) have been found in many other species including deer, pronghorn (Antilocapra americana),

Recombinant Vesicular Stomatitis Virus Vaccine Vectors ~ Author Summary Ebola and Marburg viruses are categorized as Category A priority pathogens by several US Government agencies as a result of their high mortality rates and potential for use as agents of bioterrorism. There are currently no vaccines or therapeutics approved for human use. A replication-competent, recombinant vesicular stomatitis virus (rVSV) vector expressing filovirus .

Recombinant Vesicular Stomatitis Virus Vaccine Vectors ~ Recombinant Vesicular Stomatitis Virus Vaccine Vectors Expressing Filovirus Glycoproteins Lack Neurovirulence in Nonhuman Primates The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Mire, Chad E., Andrew D. Miller, Angela Carville, Susan V.

Definition of recombinant vesicular stomatitis virus ~ A recombinant, replicating oncolytic vesicular stomatitis virus (VSV) carrying the human interferon-beta (IFN-b) gene, with potential immunomodulating and antineoplastic activities. Upon intratumoral administration, recombinant VSV expressing IFN-b replicates in the tumor environment specifically, partially due to defective innate antiviral host defense mechanisms in tumor cells, involving .

Single injection recombinant vesicular stomatitis virus ~ Single-injection recombinant vesicular stomatitis virus (rVSV) vectors have been developed as vaccine candidates against many important human pathogens such as papillomavirus [15, 16], human immunodeficiency virus (HIV) [17–19], influenza virus , measles virus [21, 22], respiratory syncytial virus [23, 24], severe acute respiratory syndrome .

Vesicular Stomatitis Virus (VSV) ~ 46 cases with New Jersey and Indiana viruses and 13 cases due to Piry virus until 1980 (with no deaths). No LAIs associated with Chandipura, Cocal, Maraba or Isfahan viruses have been reported. Sources: Exposure of skin and mucous membranes to VSV by direct contact with contaminated sources, percutaneous exposure.

Indiana vesiculovirus - Wikipedia ~ Indiana vesiculovirus, formerly Vesicular stomatitis Indiana virus (VSIV or VSV) is a virus in the family Rhabdoviridae; the well-known Rabies lyssavirus belongs to the same family. VSIV can infect insects, cattle, horses and pigs.It has particular importance to farmers in certain regions of the world where it infects cattle. This is because its clinical presentation is identical to the very .

Recombinant Vesicular Stomatitis Virus Expressing ~ Live attenuated vaccine vectors based on recombinant vesicular stomatitis viruses (rVSVs) expressing foreign antigens are highly effective vaccines in animal models. In this study, we report that an rVSV expressing influenza nucleoprotein (VSV NP) from the first position of the VSV genome induces robust anti-NP CD8 T cells in immunized mice.