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Development of an AcidResistant Salmonella Typhi Ty21a Attenuated Vector For Improved Oral Vaccine Delivery

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Development of an Acid-Resistant Salmonella Typhi Ty21a ~ The licensed oral, live-attenuated bacterial vaccine for typhoid fever, Salmonella enterica serovar Typhi strain Ty21a, has also been utilized as a vaccine delivery platform for expression of diverse foreign antigens that stimulate protection against shigellosis, anthrax, plague, or human papilloma virus. However, Ty21a is acid-labile and, for effective oral immunization, stomach acidity has .

Development of an Acid-Resistant Salmonella Typhi Ty21a ~ Development of an Acid-Resistant Salmonella Typhi Ty21a Attenuated Vector For Improved Oral Vaccine Delivery. . However, the ECC was selected as a more practical delivery format for both packaging/shipping and vaccine administration ease. We have sought to increase Ty21a acid-resistance to allow for removal from the ECC and immune enhancement.

Development of an Acid-Resistant Salmonella Typhi Ty21a ~ Abstract. The licensed oral, live-attenuated bacterial vaccine for typhoid fever, Salmonella enterica serovar Typhi strain Ty21a, has also been utilized as a vaccine delivery platform for expression of diverse foreign antigens that stimulate protection against shigellosis, anthrax, plague, or human papilloma virus.

US20180264099A1 - Live attenuated oral vaccine against ~ Disclosed is the attenuated Salmonella typhi vaccine Ty21a utilized as a vector for Shigella and/or enterotoxogenic E. coli genes stably integrated in the Ty21a chromosome. These genes include a heterologous Shigella sonnei O-antigen biosynthetic gene region that comprises the wzz gene and expresses Shigella sonnei form 1 O-antigen, as well as a heterologous acid resistance biosynthetic gene .

Genome Sequence of Salmonella enterica Serovar Typhi Oral ~ Attenuated Salmonella enterica serovar Typhi strain Ty21a is an important vaccine for controlling typhoid fever and serves as an oral vector for delivering heterologous antigens. The key attenuating features of this randomly mutated strain remain in question. Genome sequencing has revealed 679 single nucleotide polymorphisms (SNPs), and will help define alterations contributing to Ty21a safety .

Protection against inhalation anthrax by immunization with ~ Dharmasena, M. N. et al. Development of an acid-resistant salmonella Typhi Ty21a attenuated vector for improved oral vaccine delivery. PLoS One 11 , e0163511 (2016).

Construction of VNP20009 / SpringerLink ~ Abstract. The engineering of tumor-targeting Salmonella strains bearing a high degree of both attenuation and tumor inhibition is a recently developed approach to vector-based treatment of cancer (1, 2).Tumor-targeted Salmonella have many desirable features for a tumor-selective delivery vehicle:

Salmonella typhi Ty21a bacterial ghost vector augments HIV ~ Here, we introduce a novel DNA vaccine delivery system based on Salmonella typhi Ty21a. Ty21a is a nonpersistent and safe oral vaccine against typhoid fever, and it has been approved by the U.S. Food and Drug Administration for human use. Additionally, it has been used as a delivery vehicle for heterologous antigens , .

Live bacterial vaccine vector and delivery strategies of ~ Attenuated S. Typhi and S. Typhimurium as live bacterial vaccine vectors have been used in many ways and shown obvious advantages for mucosal immunization: 1) Salmonella can overcome the gastric acid barrier of the stomach and eventually drain into the small intestine, the portal for invasion into deeper tissues and development of systemic .

A method to generate recombinant Salmonella typhi Ty21a ~ Live attenuated Salmonella enterica serovar Typhi Ty21a (Ty21a) is an important vaccine strain used in clinical studies for typhoid fever and as a vaccine vector for the expression of heterologous antigens. To facilitate the use of Ty21a in such studies, it is desirable to develop improved strategies that enable the stable chromosomal integration and expression of multiple heterologous antigens.

Frontiers / Manipulation of Salmonella Typhi Gene ~ Although immunity induced by typhoid fever is moderated and short-lived, typhoid vaccination with the attenuated Ty21a oral vaccine generates long-lasting protection rates reaching up to 92%. Thus, there are important differences on how wild-type Salmonella and typhoid vaccine strains stimulate host immunity. We hypothesize that vaccine strains with different mutations might affect gut .

Live-Attenuated Bacterial Vectors: Tools for Vaccine and ~ Genetically attenuated microorganisms, including pathogenic and commensal bacteria, can be engineered to carry and deliver heterologous antigens to elicit host immunity against both the vector as well as the pathogen from which the donor gene is derived. These live attenuated bacterial vectors have been given much attention due to their capacity to induce a broad range of immune responses .

Drug-Resistant Salmonella Serotype Typhi ~ Salmonella. Typhi bacteria cause typhoid fever, a potentially life-threatening disease. Symptoms include high . fever, abdominal pain, and headache. Infection can lead to bowel rupture, shock, and death. WHAT YOU NEED TO KNOW Salmonella. Typhi causes an estimated 5,700 infections and 620 hospitalizations each year in the United States.

Viruses / Free Full-Text / Recombinant Salmonella enterica ~ The HIV/AIDS epidemic remains a global health problem, especially in Sub-Saharan Africa. An effective HIV-1 vaccine is therefore badly required to mitigate this ever-expanding problem. Since HIV-1 infects its host through the mucosal surface, a vaccine for the virus needs to trigger mucosal as well as systemic immune responses. Oral, attenuated recombinant Salmonella vaccines offer this .

Salmonella Typhi ~ Salmonella Typhi pass through fecal contaminated food or drinking water in the gastrointestinal tract. Is excreted in the urine or faeces. The minimum infectious dose is less than salmonella enteritis. Typhi and parathyroid fever A, B and C are septicaemic disease. After passing through the intestinal wall is the lymphatic and hematogenous .

Identification of Five Novel Salmonella Typhi-Specific ~ Salmonella Typhi ( S . Typhi) causes typhoid fever which is a disease characterised by high mortality and morbidity worldwide. In order to curtail the transmission of this highly infectious disease, identification of new markers that can detect the pathogen is needed for development of sensitive and specific diagnostic tests. In this study, genomic comparison of<i> S</i>.

Emergence of Extensively Drug-Resistant Salmonella Typhi ~ In February 2018, a typhoid fever outbreak caused by Salmonella enterica serotype Typhi (Typhi), resistant to chloramphenicol, ampicillin, trimethoprim-sulfamethoxazole, fluoroquinolones, and third-generation cephalosporins, was reported in Pakistan. During November 2016–September 2017, 339 cases of this extensively drug-resistant (XDR) Typhi strain were reported in Pakistan, mostly in .

5. Predictions of Vaccine Development / New Vaccine ~ (Infants at earliest possible age, preferably with oral polio vaccine) Attenuated high passage bovine rotavirus. 10. 0.90. Attenuated low passage bovine rotavirus. 30. 0.80. Rhesus monkey rotavirus. 30. 0.80. Salmonella typhi (Children; young adults at risk; travelers from developed countries to endemic areas) Attenuated ga1E mutant S. typhi .

A Low Gastric pH Mouse Model to Evaluate Live Attenuated ~ Introduction. Live recombinant attenuated Salmonella vaccines (RASVs) for humans are typically derived from Salmonella enterica serovar Typhi. However, S. Typhi is host restricted to humans, thus preclinical vaccine research and development relies on the closely related Salmonella enterica serovar Typhimurium as a model, since S. Typhimurium causes a disease in mice very similar to human typhoid .

Salmonella enterica subsp. enterica - Wikipedia ~ The short form lists the genus, Salmonella, which is followed by the capitalized and non-italicized serovar. The full designation for Salmonella Typhi is Salmonella enterica subsp. enterica, serovar Typhi. Each serovar can have many strains, as well, which allows for a rapid increase in the total number of antigenically variable bacteria.

Low-pH Rescue of Acid-Sensitive Salmonella enterica ~ The vast majority of live attenuated Salmonella vaccines for humans are constructed from Salmonella enterica serovar Typhi strain Ty2, an rpoS mutant . In addition to the rpoS mutation derived from its parent strain Ty2, the licensed typhoid vaccine strain Ty21a carries galE and tvi mutations as well as a number of other, less well .