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Approaches to improve the oral bioavailability and effects ~ Background: The poor bioavailability of Berberine (BBR) and Betulinic acid (BA) limits the development of these promising anticancer agents for clinical use. In the current study, BBR and BA in spray dried (SD) mucoadhesive microparticle formulations were prepared. Methods: A patented dual channel spray gun technology established in our laboratory was used for both formulations.
Approaches to Improve the Oral Bioavailability and Effects ~ Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid Article (PDF Available) in PLoS ONE 9(3):e89919 · March 2014 with 534 Reads
Approaches to Improve the Oral Bioavailability and Effects ~ Citation: Godugu C, Patel AR, Doddapaneni R, Somagoni J, Singh M (2014) Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid. PLoS ONE 9(3): e89919.
Approaches to Improve the Oral Bioavailability and Effects ~ DOI: 10.1371/journal.pone.0089919 Corpus ID: 592833. Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid @article{Godugu2014ApproachesTI, title={Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid}, author={Chandraiah Godugu and Apurva R. Patel and R. Doddapaneni and .
Approaches to improve the oral bioavailability and effects ~ Approaches to improve the oral bioavailability and effects of novel anticancer drugs berberine and betulinic acid. Chandraiah Godugu College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, Florida, United States of America.
Approaches to Improve the Oral Bioavailability and Effects ~ Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid By Chandraiah Godugu, Apurva R. Patel, Ravi Doddapaneni, Jaganmohan Somagoni and Mandip Singh
Potential cytotoxic and anti-metastatic effects of ~ To improve berberine aqueous solubility and oral bioavailability, several approaches including altering the structure of berberine or co-administering berberine with an absorption enhancer, . M. SinghApproaches to improve the oral bioavailability and effects of novel anticancer drugs berberine and betulinic acid.
Berberine, an Isoquinoline Alkaloid, Inhibits the ~ Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid. PLoS ONE 2014, 9 (3) , e89919. DOI: 10.1371/journal.pone.0089919. Honghai Zhao, Tongen Zhang, Chun Xia, Lei Shi, Shaojie Wang, Xinpeng Zheng, Tianhui Hu, Bing Zhang.
Novel Gefitinib Formulation with Improved Oral ~ Oral administration of anticancer agents presents a series of advantages for patients. However, most of the anticancer drugs have poor water solubility leading to low bioavailability. Controlled released spray dried matrix system of Gefitinib with hydroxypropyl β-cyclodextrin, chitosan, hydroxy propyl methyl cellulose, vitamin E TPGS, succinic acid were used for the design of formulations to .
Novel cremochylomicrons for improved oral bioavailability ~ C. Godugu, A.R. Patel, R. Doddapaneni, J. Somagoni, M. SinghApproaches to improve the oral bioavailability and effects of novel anticancer drugs berberine and betulinic acid PLoS One, 9 (2014), p. e89919
Research Progress on Berberine With a Special Focus on Its ~ Approaches to improve the oral bioavailability and effects of novel anticancer drugs berberine and betulinic acid. Godugu C, Patel AR, Doddapaneni R, Somagoni J, Singh M. Godugu C, et al. PLoS One. 2014 Mar 10;9(3):e89919. doi: 10.1371/journal.pone.0089919. eCollection 2014.
Oral Anticancer Drugs: Mechanisms of Low Bioavailability ~ The use of oral anticancer drugs has increased during the last decade, because of patient preference, lower costs, proven efficacy, lack of infusion-related inconveniences, and the opportunity to .
Frontiers / Cocrystal Formation of Betulinic Acid and ~ Betulinic acid (BA) was demonstrated to be a very promising anticancer agent against various tumor cell lines such as breast, colon, lung, and brain. Despite its strong cytotoxic effect, betulinic acid exhibits low water solubility, feature that is reflected in its poor bioavailability. To overcome these drawbacks, numerous strategies were conducted to improve its physicochemical and .
Oral Anticancer Drugs: Mechanisms of Low Bioavailability ~ The use of oral anticancer drugs has increased during the last decade, because of patient preference, lower costs, proven efficacy, lack of infusion-related inconveniences, and the opportunity to develop chronic treatment regimens. Oral administration of anticancer drugs is, however, often hampered by limited bioavailability of the drug, which is associated with a wide variability.
Oral Bioavailability / Wiley Online Books ~ "This book comprehensively covers the topics and issues of oral bioavailability and applications in drug development. The book helps readers master the basic terminology of the field, understand the basic barriers to oral bioavailability, be acquainted with the methods used to determine relevant parameters, and comprehend the challenge associated with oral drug delivery."
Sachdeva - Published Papers - Google Sites ~ Approaches to improve the oral bioavailability and effects of novel anticancer drugs berberine and betulinic acid. PLoS One. 2014 Mar 10;9(3):e89919. doi: 10.1371/journal.pone.0089919. PMID: 24614362
Reversal of drug-resistance by noscapine chemo ~ Nos oral administration enhanced the anticancer activity of DTX in drug resistant TNBC by enhancing the tumor bioavailability of DTX liposomes and chemo-sensitizing the tumor to DTX.
Letter to the editor: RECENT STUDIES ON BETULINIC ACID AND ~ Singh M. Approaches to improve the oral bioavaila-bility and effects of novel anticancer drugs berberine and betulinic acid. PLoS One. 2014;9:e89919. Jin KS, Oh YN, Hyun SK, Kwon HJ, Kim BW. Betu-linic acid isolated from Vitis amurensis root inhibits 3-isobutyl-1-methylxanthine induced melanogenesis via the regulation of MEK/ERK and PI3K/Akt path-
Bio-Sketch – FAMU College of Pharmacy ~ Chandu Godugu, Apurva Patel and Mandip Singh. Approaches to improve the oral bioavailability and effects of novel anticancer drugs berberine and betulinic acid. PLoS One. 2014 Mar 10;9(3):e89919. doi: 10.1371/journal.pone.0089919. eCollection 2014.
Preparation, characterization, and evaluation of antitumor ~ Godugu C, Patel AR, Doddapaneni R, Somagoni J, Singh M. Approaches to improve the oral bioavailability and effects of novel anticancer drugs berberine and betulinic acid. PLoS One. 2014; 9 (3):1–15. [PMC free article]
Diverse approaches for the enhancement of oral drug ~ In this review, an attempt has been made to explore various approaches that have been used in recent years to improve oral drug bioavailability, including physical and chemical means. This review strives to provide a comprehensive overview of advances made over the past 10 years (2000-2010) in the improvement of the oral bioavailability of drugs.
Mitochondria and NMDA Receptor-Dependent Toxicity of ~ Godugu C, Patel AR, Doddapaneni R, Somagoni J, Singh M (2014) Approaches to improve the oral bioavailability and effects of novel anticancer drugs berberine and betulinic Acid. PLoS One 9: e89919. [PMC free article]
Anti-Cancer Agents in Medicinal Chemistry / Bentham Science ~ Aims & Scope Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents. Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only .
Hydrastine Pharmacokinetics and Metabolism after a Single ~ (2014) Approaches to improve the oral bioavailability and effects of novel anticancer drugs berberine and betulinic acid. PLoS ONE 9 : e89919 . OpenUrl CrossRef PubMed
Oral Bioavailability: Basic Principles, Advanced Concepts ~ Understand and assess the design, delivery, and efficacy of orally administered drugs. A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists .